在乌干达穆拉戈国家转诊医院，患有子痫前期和严重症状的妇女中高血压、蛋白尿和急性肾损伤的产后缓解:一项队列研究

IF 0.8 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

African Health Sciences Pub Date : 2023-10-11 DOI:10.4314/ahs.v23i3.6

Kasereka Muteke, Milton W Musaba, David Mukunya, Jolly Beyeza, Julius N Wandabwa, Paul Kiondo

{"title":"在乌干达穆拉戈国家转诊医院，患有子痫前期和严重症状的妇女中高血压、蛋白尿和急性肾损伤的产后缓解:一项队列研究","authors":"Kasereka Muteke, Milton W Musaba, David Mukunya, Jolly Beyeza, Julius N Wandabwa, Paul Kiondo","doi":"10.4314/ahs.v23i3.6","DOIUrl":null,"url":null,"abstract":"Background: The resolution of hypertension, proteinuria and AKI postpartum among women with preeclampsia is not well documented in Uganda. Objective: To determine the time to resolution of hypertension, proteinuria and AKI postpartum until 6 weeks among women with preeclampsia in Mulago Hospital, Uganda. Methods: Between August 2017 and April 2018, we measured blood pressure, urine protein and serum creatinine on days 1,7,21 and 42 postpartum among 86 women with preeclampsia. The primary outcomes were time to the resolution of hypertension, proteinuria and AKI. We fitted accelerated failure models using Stata 17’s stintreg. command with a log normal distribution and obtained time ratios of selected exposures on time to resolution of hypertension, proteinuria and AKI intervals. Results: The median time to resolution of hypertension, proteinuria and AKI was seven (7) days (Inter quartile range, IQR 1-21). The time to resolution of hypertension among primiparous women was 3.5 times that of multiparous women [TR 3.5, 95%CI 1.1, 11.3]. No differences were observed in resolution of hypertension, proteinuria and acute kidney injury. Conclusion: The time to resolution of hypertension, proteinuria and AKI was seven days. We recommend larger studies with longer follow-up beyond six-weeks postpartum to inform revision of our guidelines. Keywords: Acute kidney injury; preeclampsia with severe features.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":"103 1","pages":"0"},"PeriodicalIF":0.8000,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Postpartum resolution of hypertension, proteinuria and acute kidney injury among women with preeclampsia and severe features at Mulago National Referral Hospital, Uganda: a cohort study\",\"authors\":\"Kasereka Muteke, Milton W Musaba, David Mukunya, Jolly Beyeza, Julius N Wandabwa, Paul Kiondo\",\"doi\":\"10.4314/ahs.v23i3.6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: The resolution of hypertension, proteinuria and AKI postpartum among women with preeclampsia is not well documented in Uganda. Objective: To determine the time to resolution of hypertension, proteinuria and AKI postpartum until 6 weeks among women with preeclampsia in Mulago Hospital, Uganda. Methods: Between August 2017 and April 2018, we measured blood pressure, urine protein and serum creatinine on days 1,7,21 and 42 postpartum among 86 women with preeclampsia. The primary outcomes were time to the resolution of hypertension, proteinuria and AKI. We fitted accelerated failure models using Stata 17’s stintreg. command with a log normal distribution and obtained time ratios of selected exposures on time to resolution of hypertension, proteinuria and AKI intervals. Results: The median time to resolution of hypertension, proteinuria and AKI was seven (7) days (Inter quartile range, IQR 1-21). The time to resolution of hypertension among primiparous women was 3.5 times that of multiparous women [TR 3.5, 95%CI 1.1, 11.3]. No differences were observed in resolution of hypertension, proteinuria and acute kidney injury. Conclusion: The time to resolution of hypertension, proteinuria and AKI was seven days. We recommend larger studies with longer follow-up beyond six-weeks postpartum to inform revision of our guidelines. Keywords: Acute kidney injury; preeclampsia with severe features.\",\"PeriodicalId\":7853,\"journal\":{\"name\":\"African Health Sciences\",\"volume\":\"103 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2023-10-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"African Health Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4314/ahs.v23i3.6\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"African Health Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/ahs.v23i3.6","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

摘要

背景:在乌干达，子痫前期妇女产后高血压、蛋白尿和AKI的解决尚未得到很好的记录。目的:了解乌干达穆拉戈医院子痫前期妇女产后6周高血压、蛋白尿和AKI的消退时间。方法:在2017年8月至2018年4月期间，我们测量了86例子痫前期妇女产后1、7、21和42天的血压、尿蛋白和血清肌酐。主要终点是高血压、蛋白尿和AKI消退的时间。我们使用Stata 17的字符串拟合加速失效模型。命令，符合对数正态分布，并获得选定暴露时间与高血压、蛋白尿和AKI时间间隔的时间比。结果:高血压、蛋白尿和AKI缓解的中位时间为7天(四分位数间距，IQR 1-21)。初产妇女高血压消退的时间是多产妇女的3.5倍[TR 3.5, 95%CI 1.1, 11.3]。在高血压、蛋白尿和急性肾损伤的消退方面，两组无差异。结论:高血压、蛋白尿和AKI的消退时间为7天。我们建议进行更大规模的研究，随访时间超过产后6周，以便为我们指南的修订提供信息。关键词:急性肾损伤;伴有严重症状的先兆子痫。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Postpartum resolution of hypertension, proteinuria and acute kidney injury among women with preeclampsia and severe features at Mulago National Referral Hospital, Uganda: a cohort study

Background: The resolution of hypertension, proteinuria and AKI postpartum among women with preeclampsia is not well documented in Uganda. Objective: To determine the time to resolution of hypertension, proteinuria and AKI postpartum until 6 weeks among women with preeclampsia in Mulago Hospital, Uganda. Methods: Between August 2017 and April 2018, we measured blood pressure, urine protein and serum creatinine on days 1,7,21 and 42 postpartum among 86 women with preeclampsia. The primary outcomes were time to the resolution of hypertension, proteinuria and AKI. We fitted accelerated failure models using Stata 17’s stintreg. command with a log normal distribution and obtained time ratios of selected exposures on time to resolution of hypertension, proteinuria and AKI intervals. Results: The median time to resolution of hypertension, proteinuria and AKI was seven (7) days (Inter quartile range, IQR 1-21). The time to resolution of hypertension among primiparous women was 3.5 times that of multiparous women [TR 3.5, 95%CI 1.1, 11.3]. No differences were observed in resolution of hypertension, proteinuria and acute kidney injury. Conclusion: The time to resolution of hypertension, proteinuria and AKI was seven days. We recommend larger studies with longer follow-up beyond six-weeks postpartum to inform revision of our guidelines. Keywords: Acute kidney injury; preeclampsia with severe features.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

African Health Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

2.30

自引率

0.00%

发文量

179

审稿时长

>12 weeks

期刊介绍： The African Health Sciences is an internationally refereed journal publishing original articles on research, clinical practice, public health, policy, planning, implementation and evaluation, in the health and related sciences relevant to Africa and the tropics. Its objectives are to: Advocate for and promote the growth of reading culture in sub Saharan Africa; Provide a high quality journal in which health and policy and other researchers and practitioners in the region can and world wide, can publish their work; Promote relevant health system research and publication in the region including alternative means of health care financing, the burden of and solution of health problems in marginalized urban and rural communities amongst the displaced and others affected by conflict; Promote research and the systematic collection and collation and publication of data on diseases and conditions of equity and influence; Promote development of evidence-based policies and guidelines for clinical, public health and other practitioners. African Health Sciences acknowledges support provided by the African Health Journals Partnership Project that is funded by the US National Institutes of Health (through the National Library of Medicine and the Fogarty International Center) and facilitated by the Council of Science Editors.