Clinical Example of Effective use of Biocompatible Magnetite (Fe3O4) Nanoparticles in the Complex Treatment of Multiple Sclerosis

Multiple Sclerosis (MS) is a multifactorial disease characterized by a variety of pathogenic mechanisms and pathways. Successful treatment of multiple sclerosis requires a fundamentally new approach in solving a number of problems related to the pathogenesis of the disease. Currently, nanotechnology opens a new stage of innovative medicine. Previously accumulated clinical experience in the use of biocompatible magnetite (Fe3 O4 ) nanoparticles, the study of their mechanisms of action on biological environments and systems of the living organism creates the preconditions for their effective use in the complex therapy of MS. The primary purpose of the study was to slow down the progression of MS, improve the neurological status and general condition of the patient, reduce the dynamics of demyelinating foci in the brain by including biocompatible Micromage-B magnetite nanoparticles in the complex therapy. Following the application of Micromage-B nano-particles in the treatment of MS, objective improvement of the neurological state, reduction of stiff-ness and rapid fatigue of the lower extremities were observed. Improved gait and coordination, de-creased trembling of the hand, depression and signs of concentration disorders gone, appetite re-stored, speech improved. During the entire period of use of Micromage-B, positive dynamic normalization of the neurological condition was observed. After six months, the total score fell from 210 to 45. The EDSS Disability Scale score has decreased from 6.0 to 5.0. Examination of the brain by MRI with contrast enhancement for the first time showed a decrease in the number of new foci of demyelinating in the brain. The procedure of restoration of the central nervous system activity in MS is due not only to the immunosuppressive properties of magnetite nanoparticles, but probably also to the activation of remyelination mechanisms and differentiation of oligodendrocytes due to enzymatic methylation. Considering the above, the use of biocompatible nanodevices in the complex treatment of MS is a promising innovative area and claims to be further considered for the purpose of subsequent inclusion of nanotechnology in the protocols for MS treatment.