经胸剪切波超声弹性成像诊断胸膜病变的验证

IF 0.8 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Yao-Wen Kuo, Yen-Lin Chen, Huey-Dong Wu, Hao-Chien Wang
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引用次数: 0

摘要

目的:本研究采用剪切波超声弹性成像测量胸膜病变的刚度。研究假设横波弹性成像可以增加胸膜病变的弹性信息,有助于胸膜疾病的诊断。方法:本前瞻性观察研究包括2018年5月至2021年10月的一个衍生队列和2021年11月至2022年8月的一个验证队列。纳入标准是胸膜病变或胸膜积液的影像学证据。我们使用东芝Aplio 500白金超声机定位胸膜病变并测量胸膜病变的弹性。诊断依据微生物学检查、胸腔积液或胸膜病理,或随访临床病程至少6个月。结果:共纳入210例胸膜病变患者。恶性胸膜病变的平均弹性明显高于良性胸膜病变(91.9 vs 61.2 kPa, p<0.001)。在衍生队列的103例患者中,构建了接受者工作特征曲线,区分良恶性病变的截断点为60.2 kPa,准确率为72.7%(敏感性81.3%,特异性57.1%,ROC曲线下面积0.69)。在验证队列中的107例患者中,诊断性能保持在73.8%的准确率。结论:本研究证实了剪切波超声弹性成像在评估胸膜恶性肿瘤中的应用。使用剪切波弹性成像引导胸膜活检的进一步研究是有必要的,以进一步研究诊断率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Validation of transthoracic shear-wave ultrasound elastography in diagnosing pleural lesions
Purpose: This study used shear-wave ultrasound elastography to measure the stiffness of pleural lesions. The research hypothesis is that shear-wave elastography can add the elasticity information of the pleural lesions and help in the diagnosis of pleural diseases. Methods: This prospective observational study included one derivation cohort from May 2018 to Oct 2021 and one validation cohort from Nov 2021 to Aug 2022. The inclusion criterion was patients with radiographic evidence of pleural lesions or pleural effusion. We used the Toshiba Aplio 500 Platinum Ultrasound Machine to locate the pleural lesions and measure the elasticity of the pleural lesions. Diagnoses were made based on microbiological studies, pathology of pleural effusion or pleura, or following up the clinical course for at least 6 months. Results: A total of 210 patients with pleural lesions were included. The mean elasticity of the malignant pleural lesions was significantly higher than that of the benign pleural lesions (91.9 vs. 61.2 kPa, p< 0.001). Among the 103 patients in the derivation cohort, a receiver operating characteristic curve was constructed and the cut-off point to differentiate benign from malignant lesions was 60.2 kPa with an accuracy of 72.7% (sensitivity 81.3%, specificity 57.1%, and area under the ROC curve 0.69). Among the 107 patients in the validation cohort, the diagnostic performance was maintained with an accuracy of 73.8%. Conclusions: This study validated the use of shear-wave ultrasound elastography for assessing pleural malignancy. Additional studies using shear-wave elastography-guided pleural biopsy are warranted to further investigate the diagnostic yield.
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来源期刊
Ultrasound
Ultrasound RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
1.70
自引率
0.00%
发文量
55
期刊介绍: Ultrasound is the official journal of the British Medical Ultrasound Society (BMUS), a multidisciplinary, charitable society comprising radiologists, obstetricians, sonographers, physicists and veterinarians amongst others.
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