Najwa Imad Sulaiman Saleh, Siham Agmee Wadee, Entedhar R. Sarhat
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引用次数: 1
摘要
阿霉素(DOX)是一种非常有效的化疗药物。然而，肝毒性降低了其在人类中的临床应用。因此，本研究旨在检测枣椰树提取物对血清抗炎标志物(白细胞介素(IL) IL- 1b、IL-6和IL-10)的影响。将40只成年大鼠分为4组(G1对照组，G2组口服DPE 2mg\kg, G3组口服DOX IP 2mg\kg, G4组每日口服DOX IP 2mg\kg和DPE 2mg\kg，连续30 d)。研究结束时，处死动物，对肝脏进行组织学分析。Dox组大鼠血清IL-1B、IL-6、IL-10水平明显高于对照组，肝脏组织病理表现为炎症、坏死。在DPE+ DOX组中，检测到DOX治疗导致血清IL-1B、IL-6和IL-10水平显著降低。总的来说，预共给药DPE通过其抗氧化、抗炎、抗纤维化和抗凋亡蛋白部分减轻了dox诱导的肝损伤。
Minimizing the side effects of Doxorubicin Induced Hepatotoxicity by using alcoholic extract of Date Palm in adult rats
Doxorubicin (DOX) is a highly effective drug for chemotherapy. However, hepatotoxicity reduces its clinical utility in humans. Thus, this study was designed to examine Date Palm extract on serum anti-inflammatory markers (interleukin(IL) IL-1B, IL-6 and IL-10). Forty adult rats were divided into 4 groups (G1 control, G2 receiving 2mg\kg of DPE orally, G3 treated with 2mg\kg of DOX IP, and G4 received 2mg\kg of DOX via IP and 2mg\kg of DPE by oral gavage daily for 30 days). At the end of the study, animals were sacrificed, and livers were analyzed histologically. The Dox group showed significantly higher levels of serum IL-1B, IL-6, and IL-10 than the control group, with inflammation and necrosis in hepatic histopathology. In the DPE+ DOX group, it was detected that DOX treatment caused a significant decrease in serum IL-1B, IL-6, and IL-10 levels. Collectively, pre-coadministration of DPE partially mitigated DOX-induced hepatic injuries via its antioxidant, anti-inflammatory, anti-fibrotic, and antiapoptotic protein.
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