膀胱输尿管反流合并慢性肾盂肾炎的肾集管移行性化生:1例免疫组织化学研究及文献复习

Q3 Medicine
Naser Tayyebi Meibodi, Salman Soltani, Farnaz Torabian
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引用次数: 0

摘要

泌尿道发生肾盂鳞状上皮、肠上皮、腺上皮、粘液上皮或纤毛上皮等化生变化的能力此前已有报道,假设这是由于移行上皮的机械刺激所致。然而,移行性化生在集合管中是一种罕见的表现。本文的目的是报道这种极其罕见的化生,并告知病理学家,他们可能会遇到这种化生。一名25岁男子,已知膀胱输尿管反流(VUR)病例,转诊至伊玛目礼萨医院;隶属于马什哈德医科大学,进行双侧肾切除术。双侧肾切除标本的大体评估显示肾脏萎缩和盆腔系统扩张。光镜下表现为慢性肾盂肾炎背景下的过渡性化生,GATA3核免疫组化染色证实。在本研究中,我们报道了一例罕见的肾集管上皮内移行上皮取代正常上皮的化生变化,并假设既往病史(包括VUR或血液透析)可能是引发化生变化的原因,有待进一步研究证实。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Transitional Metaplasia of Renal Collecting Ducts in Vesicoureteral Reflux and Chronic Pyelonephritis: An Immunohistochemical Study of a Case and Review of the Literature
The capability of the urinary tract to undergo metaplastic changes such as squamous, intestinal, glandular, mucinous, or ciliated epithelium in renal pelvis has been previously reported, which hypothetically is due to the mechanical irritation of the transitional epithelium. However, transitional metaplasia is a rare presentation in the collecting ducts. The aim of this paper was to report this type of extremely rare metaplasia and to inform pathologists that they may encounter this kind of metaplasia. A 25-year-old man, a known case of vesicoureteral reflux (VUR), referred to the Imam Reza Hospital; affiliated to the Mashhad University of Medical Sciences, for bilateral nephrectomy. Gross evaluation of bilateral nephrectomy specimens showed atrophic kidneys and dilated pelvicalyceal systems. The light microscopic evaluation showed transitional metaplasia in the background of chronic pyelonephritis, confirmed by GATA3 nuclear immunohistochemical stain. In this study, we presented a rare case of a renal collecting duct with transitional epithelial lining replacing the normal epithelium as a metaplastic change, with the hypothesis that previous medical history including VUR, or hemodialysis could be the trigger for the metaplastic change, which should be confirmed by further studies.
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来源期刊
Iranian Journal of Pathology
Iranian Journal of Pathology Medicine-Pathology and Forensic Medicine
CiteScore
2.00
自引率
0.00%
发文量
99
审稿时长
20 weeks
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