The combination of atorvastatin with Proanthocyanidin enhances antioxidant and reactive oxidative stress on HepG2 hepatocellular Carcinoma Cells.

Keywords The purpose of this study was to measure the antioxidant state and reactive oxidative stress in the HPG2 cell line in order to explore the effects of Taxol, Atorvastatin, and proanthocynadin. In this study, the effects of Atorvastatin, a novel 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, and Proanthocynadin, the most prevalent polyphenol class in the human diet, on a range of metabolic diseases and chemotherapeutic effects were investigated, Taxol, a chemotherapeutic drug is substance derived from the bark and trunk of the Yew Pacific tree, was shown to assist induce and enhance tubulin polymerization and assembly while also preventing its depolymerization effects on oxidative stress and antioxidant enzymes. Taxol, Atorvastatin, and Proanthcyanidin inhibited the viability of HepG2 cells in a time-and dose-dependent manner, Superoxide dismutase (SOD) and catalase antioxidant enzyme activities were dramatically reduced as a result of the treatment, but glutathione reductase activity, malondialdehyde (MDA) concentrations, and malondialdehyde reductase activity were all significantly higher in treated groups than in untreated cells.