多细胞动物的再生和再生长源于其生命周期中存在的器官变态和持续生长过程

IF 1.1 4区 生物学 Q4 ANATOMY & MORPHOLOGY
Acta Zoologica Pub Date : 2023-10-29 DOI:10.1111/azo.12487
Lorenzo Alibardi
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引用次数: 0

摘要

本综述提出了无脊椎动物和脊椎动物再生分布的进化假说。再生是生活在水环境中的动物产生生命的基本祖先属性。各门类演化出的特定生命周期表明,只有具有无性生殖、幼虫阶段和变态的成年水生动物、原生动物或脱胎动物才具有广泛的再生能力。再生源于以不同形式重新利用在发育和幼虫变态过渡阶段活跃的众多发育基因途径。受伤的成年动物由已分化的组织组成,无法重复胚胎发育过程中的相同基因激活序列,导致再生能力参差不齐(大多数水生无脊椎动物和无脊椎动物)。与此相反,基因组中没有产生幼虫和强烈变态程序的物种(主要是陆生物种)(许多线虫、节肢动物和羊膜动物)在受伤后无法再生其器官。据推测,在陆生动物的进化过程中,它们失去了参与再生的基因,因此只能通过与生长(regengrow)相关的伤口愈合或疤痕修复。未来有关再生能力强的动物的发育途径的分子知识将告诉我们,再生能力弱的动物的器官再生是否可行。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Regeneration and regengrow in multicellular animals derive from the presence of processes of organ metamorphosis and continuous growth in their life cycles

The present review formulates an evolutionary hypothesis on the distribution of regeneration in invertebrates and vertebrates. Regeneration is a basal ancestral property of animals living in aqueous environment where life was generated. The specific life cycles that evolved in each phylum indicate that only adult aquatic animals with asexual reproduction, larval stages and metamorphosis, possess broad regenerative abilities, protostomes or deuterostomes. Regeneration derives from the re-utilization in different forms of numerous developmental gene pathways active during development and the transitional phases of larval metamorphosis. An injured adult animal, composed of differentiated tissues, cannot repeat the same sequence of gene activation of embryogenesis, resulting in a variable regeneration (most aquatic invertebrates and anamiotes). In contrast, species with a genome that is not programmed for producing larvae and intense metamorphosis, mainly terrestrial (numerous nematodes, arthropods and amniotes), cannot regenerate their organs after injury. It is hypothesized that during the evolution of terrestrial animals, they lost genes involved in regeneration so that they repair by wound healing associated with grow (regengrow) or by scarring. Future molecular knowledge on developmental pathways that evolved in regenerating competent animals will tell us whether or not organ regeneration in regenerative incompetent animals will be feasible.

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来源期刊
Acta Zoologica
Acta Zoologica 生物-动物学
CiteScore
2.90
自引率
8.30%
发文量
35
审稿时长
>12 weeks
期刊介绍: Published regularly since 1920, Acta Zoologica has retained its position as one of the world''s leading journals in the field of animal organization, development, structure and function. Each issue publishes original research of interest to zoologists and physiologists worldwide, in the field of animal structure (from the cellular to the organismic level) and development with emphasis on functional, comparative and phylogenetic aspects. Occasional review articles are also published, as well as book reviews.
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