子宫肌瘤的全球流行病学特征

IF 3 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Archives of Medical Science Pub Date : 2023-10-30 DOI:10.5114/aoms/171786

Bo Li, Fangfang Wang, Lingying Chen, Haofei Tong

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In contrast, the global age-standardized DALY rate decreased from 1990 to 2019, with an EAPC of –0.27 (95% CI: –0.31 to –0.23). High and low-middle SDI regions experienced significantly higher age-standardized incidence rates. Moreover, in 2019, low and low-middle SDI regions had significantly higher age-standardized DALY rates due to uterine fibroids than other SDI regions. Regionally, Eastern Europe had the highest age-standardized incidence rate of uterine fibroids in 2019, and Tropical Latin America experienced the greatest increase in age-standardized incidence rates from 1990 to 2019. Nationally, Brazil (EAPC = 1.46; 95% CI: 1.35–1.57) and India (EAPC = 1.09; 95% CI: 0.94–1.25) experienced the most significant increases in age-standardized uterine fibroid incidence. Age-standardized DALY rates increased the most in Tropical Latin America, high-income North America and Oceania. 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引用次数: 0

摘要

本研究的目的是在年龄和社会人口指数(SDI)方面检查全球，地区和国家层面的子宫肌瘤负担。数据提取自GBD 2019数据集。计算估计的年百分比变化(EAPCs)来评估子宫肌瘤的发病率，并检查残疾调整生命年(DALYs)的趋势。所有检查的措施都按地区、国家、年龄和SDI进行分层，以评估这些变量对子宫肌瘤发病率的影响。结果1990 - 2019年，全球年龄标准化子宫肌瘤发病率呈上升趋势，EAPC为0.25(95%可信区间(CI): 0.24 ~ 0.27)。相比之下，全球年龄标准化DALY率从1990年到2019年下降，EAPC为-0.27 (95% CI: -0.31至-0.23)。SDI高、中低地区的年龄标准化发病率显著高于其他地区。此外，2019年低、中低SDI地区因子宫肌瘤的年龄标准化DALY率明显高于其他SDI地区。从区域来看，东欧在2019年子宫肌瘤的年龄标准化发病率最高，热带拉丁美洲在1990 - 2019年的年龄标准化发病率增幅最大。在全国范围内，巴西(EAPC = 1.46;95% CI: 1.35-1.57)和印度(EAPC = 1.09;95% CI: 0.94-1.25)年龄标准化子宫肌瘤发病率显著增高。拉丁美洲热带地区、北美高收入地区和大洋洲的年龄标准化DALY率增幅最大。结论近年来，在全球范围内，子宫肌瘤的年龄标准化发病率呈上升趋势。相反，年龄标准化的DALY率呈现下降趋势。东欧、热带拉丁美洲、巴西和印度的子宫肌瘤负担最重。在全球范围内，35-39岁及以上的女性患子宫肌瘤的风险增加，这反映在这些年龄组的发病率较高。

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Global epidemiological characteristics of uterine fibroids

Introduction The aim of the study was to examine the burden of uterine fibroids at global, regional and national levels in terms of age and the Socio-demographic Index (SDI). Material and methods Data were extracted from the GBD 2019 dataset. Estimated annual percentage changes (EAPCs) were calculated to assess the incidence of uterine fibroids, and trends in disability-adjusted life years (DALYs) were examined. All measures examined were stratified by region, country, age and SDI to assess the effects of these variables on the incidence of uterine fibroids. Results The global age-standardized incidence rate of uterine fibroids increased from 1990 to 2019, with an EAPC of 0.25 (95% confidence interval (CI): 0.24 to 0.27). In contrast, the global age-standardized DALY rate decreased from 1990 to 2019, with an EAPC of –0.27 (95% CI: –0.31 to –0.23). High and low-middle SDI regions experienced significantly higher age-standardized incidence rates. Moreover, in 2019, low and low-middle SDI regions had significantly higher age-standardized DALY rates due to uterine fibroids than other SDI regions. Regionally, Eastern Europe had the highest age-standardized incidence rate of uterine fibroids in 2019, and Tropical Latin America experienced the greatest increase in age-standardized incidence rates from 1990 to 2019. Nationally, Brazil (EAPC = 1.46; 95% CI: 1.35–1.57) and India (EAPC = 1.09; 95% CI: 0.94–1.25) experienced the most significant increases in age-standardized uterine fibroid incidence. Age-standardized DALY rates increased the most in Tropical Latin America, high-income North America and Oceania. Conclusions Globally, the age-standardized incidence of uterine fibroids has been increasing in recent years. In contrast, age-standardized DALY rates have exhibited a decreasing trend. Eastern Europe, Tropical Latin America, Brazil and India experience the greatest uterine fibroid burden. Globally, women aged 35–39 years and older have an increased risk of uterine fibroids, as reflected in the higher incidence rates among these age groups.

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来源期刊

Archives of Medical Science 医学-医学：内科

CiteScore

4.90

自引率

7.90%

发文量

139

审稿时长

1.7 months

期刊介绍： Archives of Medical Science (AMS) publishes high quality original articles and reviews of recognized scientists that deal with all scientific medicine. AMS opens the possibilities for young, capable scientists. The journal would like to give them a chance to have a publication following matter-of-fact, professional review by outstanding, famous medical scientists. Thanks to that they will have an opportunity to present their study results and/or receive useful advice about the mistakes they have made so far. The second equally important aim is a presentation of review manuscripts of recognized scientists about the educational capacity, in order that young scientists, often at the beginning of their scientific carrier, could constantly deepen their medical knowledge and be up-to-date with current guidelines and trends in world-wide medicine. The fact that our educational articles are written by world-famous scientists determines their innovation and the highest quality.