CORRELATION BETWEEN CALCIUM SENSING RECEPTOR WITH CALCIUM HOMEOSTASIS IN MAJOR β-THALASSEMIA PATIENTS

: The extracellular calcium ion (Ca 2+ )-sensing receptor (CaSR) enables key tissues that maintain Ca 2+ homeostasis to sense changes in the Ca 2+ concentration. These tissues respond to changes in Ca 2+ with functional alterations that will help restore Ca 2+ to normal. This study was conducted to evaluate the calcium sensing receptor as predictive Biomarkers for detection the bone turnover in major βββββ -thalassemia patients. (95) sample individuals were collected, (65) of them were â-thalassemia patients (31 males and 34 female), which attended to thalassemia center at Azadi Teaching Hospital in Kirkuk city and the remaining (30) individuals (15 males and 15 female) were apparently healthy subjects with age ranged from (18-45) years. Total individuals had hormonal assay calcium sensing receptor (CaSR) and biochemical assay (calcium, ionized calcium, corrected calcium and Albumin ). CaSR levels increased with no significant difference (P>0.05) but Calcium, corrected calcium, ionized Calcium and Albumin levels decreased with no significant difference (P>0.05) in βββββ -thalassemia patients when compared with control group. It was concluded that bone health compromised in major βββββ -thalassemia and bone related hormones and biochemical abnormalities, these results due to iron over load or due to nutrition deficiency.