狼疮肾病和肾移植的性别差异

Marcora Mandreoli
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引用次数: 0

摘要

系统性红斑狼疮(SLE)在女性中有明显的患病率。虽然有相互矛盾的数据,但在SLE患者中,男性患狼疮性肾炎的比例更高,其组织学和临床模式比女性更严重。更常见的是,男性也会出现抗磷脂综合征。男性不太可能达到狼疮肾炎的临床缓解。性别和性别差异也存在于肾移植之前的所有阶段,从推荐资格到登记在积极的等待名单上。保健人员有一种看法,认为妇女的身体更脆弱,因此不太适合进行肾移植。妇女在完成列入等候名单所需的检查方面也遇到障碍,而且在许多保健情况下,她们接受移植的可能性较小。在活体移植领域,妇女占所有捐献者的一半以上,而男性则主要是接受者。女性患者和移植物的长期存活似乎优于男性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sex and gender disparities in lupus nephropathy and kidney transplantation
Systemic lupus erythematosus (SLE) has a clear prevalence in females. Although there are conflicting data, among males affected by SLE a higher proportion develops lupus nephritis, with a more severe histological and clinical pattern than in females. More frequently males also present an antiphospholipid syndrome. Males are less likely to achieve clinical remission of lupus nephritis. A sex and gender disparity is also present in all the phases preceding the kidney transplant from the referral for eligibility to the registration on the active waiting list. There is a perception among healthcare staff that women have a greater degree of fragility and are therefore less eligible for kidney transplantation. Women also encounter obstacles in completing the tests necessary for inclusion in the waiting list and in many Health Care contexts they are less likely to have a transplant. In the field of living transplantation, women represent over half of all donors, while males are predominantly recipients. Long-term patient and graft survival appears superior in women than in men.
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