通过模块组装工程血管化的器官型组织

IF 16.1 1区工程技术 Q1 ENGINEERING, MANUFACTURING

International Journal of Extreme Manufacturing Pub Date : 2023-10-11 DOI:10.1088/2631-7990/acfcf2

Zhenzhen Zhou, Changru Liu, Yuting Guo, Yuan Pang, Wei Sun

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引用次数: 0

摘要

充分的血管化是复杂器官型组织模型成功构建和临床实施的关键决定因素。目前，由于细胞和血管密度低，血管成熟度不够，使得血管化器官型组织构建困难，极大地限制了其在组织工程和再生医学中的应用。为了解决这些限制，最近的研究采用了预血管化微组织组装来快速生成具有致密血管网络和高细胞密度的功能组织类似物。本文综述了基于模块组装的血管化器官型组织构建及其在组织修复与再生、器官尺度组织生物制造、高级组织建模等方面的应用进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Engineering vascularized organotypic tissues via module assembly

Abstract Adequate vascularization is a critical determinant for the successful construction and clinical implementation of complex organotypic tissue models. Currently, low cell and vessel density and insufficient vascular maturation make vascularized organotypic tissue construction difficult, greatly limiting its use in tissue engineering and regenerative medicine. To address these limitations, recent studies have adopted pre-vascularized microtissue assembly for the rapid generation of functional tissue analogs with dense vascular networks and high cell density. In this article, we summarize the development of module assembly-based vascularized organotypic tissue construction and its application in tissue repair and regeneration, organ-scale tissue biomanufacturing, as well as advanced tissue modeling.

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来源期刊

International Journal of Extreme Manufacturing Engineering-Industrial and Manufacturing Engineering

CiteScore

17.70

自引率

6.10%

发文量

审稿时长

12 weeks

期刊介绍： The International Journal of Extreme Manufacturing (IJEM) focuses on publishing original articles and reviews related to the science and technology of manufacturing functional devices and systems with extreme dimensions and/or extreme functionalities. The journal covers a wide range of topics, from fundamental science to cutting-edge technologies that push the boundaries of currently known theories, methods, scales, environments, and performance. Extreme manufacturing encompasses various aspects such as manufacturing with extremely high energy density, ultrahigh precision, extremely small spatial and temporal scales, extremely intensive fields, and giant systems with extreme complexity and several factors. It encompasses multiple disciplines, including machinery, materials, optics, physics, chemistry, mechanics, and mathematics. The journal is interested in theories, processes, metrology, characterization, equipment, conditions, and system integration in extreme manufacturing. Additionally, it covers materials, structures, and devices with extreme functionalities.