EXERT-BC: Prospective study of an exercise regimen after the treatment for breast cancer

EXERT-BC is a dose-escalated resistance training regimen created to improve body composition, strength, and balance in women treated for breast cancer. Herein, we report the interim analysis. Women treated for BC underwent this 3-month exercise regimen in an exercise oncology facility with continual monitoring of load and strength. 20 women completed the IRB-approved protocol, with a mean age of 57 years (range 41-74). Concurrent therapies included anti-estrogen therapy (73%), chemotherapy (14%), and radiotherapy (23%). 27% of women endorsed prior exercise. Subjects missed an average of 1.75 classes (range 0-7), with all meeting adherence over 75%. No injuries or adverse events were reported aside from muscle soreness and 2 days of knee pain. Significant differences in body composition at completion included reduced body fat (38.2% vs 36.7%, p=0.003), and increased muscle mass (33.1% vs 37.1%, p<0.001), functional mobility screening (9.82 vs 11.73, p=0.018), and Y-balance (left: 72.4 vs 85.3, p=0.001; right: 70.3 vs 85.2. p<0.001). Significant increases in load were demonstrated: split squat (p<0.001), trap bar deadlift (p=0.035), inclined dumbbell press (p<0.001), and bird dog rows (p<0.001). A dose-escalated resistance training in women with BC is safe and feasible, endorsing significant improvements across body composition, balance, and strength.