The Impact of B12 Vitamin and Folate Deficiency on Depression Levels in Breast Cancer Patients

Objective: This study aims to investigate the impact of B12 vitamin and folate deficiency on depression levels in breast cancer patients. Material and Methods: A total of 99 breast cancer patients were included in the study, and sociodemographic data, treatment information, and lifestyle factors were recorded. Depression levels were evaluated using the Beck Depression Inventory, and B12 and folate levels were measured through laboratory tests. Statistical analyses were performed using the SPSS software, and the Mann-Whitney U test was used. Results: Patients who smoked and used alcohol had significantly higher depression scores (p=0.009 and p=0.028, respectively). Additionally, patients with low B12 vitamin levels had significantly higher depression scores (p=0.036). Similarly, patients with folate deficiency also had higher depression scores (p=0.015). Conclusion: This study demonstrates that B12 and folate deficiency can increase depression levels in breast cancer patients. Correcting B12 and folate levels in the management of depression may help improve the quality of life and positively influence the treatment process. Regular monitoring of B12 and folate levels and providing necessary treatment and support are essential in clinical practice.