培养的兔主动脉平滑肌细胞分泌一种不同于血小板衍生生长因子的新型生长因子——平滑肌细胞衍生生长因子

IF 3 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

FEBS Letters Pub Date : 1988-03-28 DOI:10.1016/0014-5793(88)80668-9

Nobuhiro Morisaki, Tetsuto Kanzaki, Tomoko Koshikawa, Yasushi Saito, Sho Yoshida

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引用次数: 0

摘要

在探讨动脉平滑肌细胞(SMC)在内膜粥样硬化病变中增殖的机制时，SMC分泌生长因子的自分泌受到了广泛的关注。本文报道了一种新的生长因子——平滑肌细胞衍生生长因子(SDGF)。培养的兔内侧SMC在无血清培养基中孵育1周，至少4代后才会分泌SDGF。SDGF与血小板衍生生长因子(PDGF)在理化、免疫学和生物学上都存在差异。SDGF的特性似乎也不同于其他已知的刺激间充质细胞增殖的生长因子。

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Secretion of a new growth factor, smooth muscle cell derived growth factor, distinct from platelet derived growth factor by cultured rabbit aortic smooth muscle cells

In attempts to determine the mechanism of proliferation of arterial smooth muscle cells (SMC) in intimal atheromatous lesions, autocrine secretion of growth factors by SMC has recently received much attention. Here we report a new growth factor named smooth muscle cell derived growth factor (SDGF). Cultured rabbit medial SMC secreted SDGF for 1 week during their incubation in serum-free media only after at least 4 passages. SDGF differed from platelet derived growth factor (PDGF) physicochemically, immunologically, and biologically. The properties of SDGF also seemed different from those of other known growth factors that stimulate the proliferation of mesenchymal cells.

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来源期刊

FEBS Letters 生物-生化与分子生物学

CiteScore

6.60

自引率

2.90%

发文量

303

审稿时长

1 months

期刊介绍： FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.