4 + 1策略合成阿努斯通样二芳基戊烷类化合物及其潜在抗癌活性评价

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Turkish Journal of Chemistry Pub Date : 2023-10-31 DOI:10.55730/1300-0527.3609

NESLİHAN ÇELEBİOĞLU, ÖZLEM ÖZDEMİR TOZLU, HASAN TÜRKEZ, HASAN SEÇEN

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引用次数: 0

摘要

合成了12个具有1,5-二芳基-1-戊烯-3- 1结构的化合物，并对其细胞毒活性进行了评价。在吡咯烷- acoh的存在下，通过4-苯基-2-丁酮和4-(4-羟基苯基)-2-丁酮的原位珐琅反应得到1,5-二烷基-1-戊烯-3- 1化合物，然后与6种不同的苯甲醛缩合。合成的化合物对人胶质母细胞瘤(U87-MG)、乳腺(MCF-7)和前列腺(PC-3)癌细胞的细胞毒活性进行了测试。一些新化合物表现出显著的细胞毒性作用，特别是对MCF-7癌细胞。

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Synthesis of alnustone-like diarylpentanoids via a 4 + 1 strategy and assessment of their potential anticancer activity

Twelve compounds with a 1,5-diaryl-1-penten-3-one structure were synthesized and their cytotoxic activities were evaluated. The 1,5-diaryl-1-penten-3-one compounds were obtained via in situ enaminations of 4-phenyl-2-butanone and 4-(4-hydroxyphenyl)-2- butanone in the presence of pyrrolidine-AcOH, followed by condensation with six different benzaldehydes. The synthesized compounds were tested for their cytotoxic activity against human glioblastoma (U87-MG), breast (MCF-7), and prostate (PC-3) cancer cell lines. Some of the novel compounds exhibited remarkable cytotoxic action, especially against MCF-7 cancer cells.

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来源期刊

Turkish Journal of Chemistry 化学-工程：化工

CiteScore

2.40

自引率

7.10%

发文量

审稿时长

3 months

期刊介绍： The Turkish Journal of Chemistry is a bimonthly multidisciplinary journal published by the Scientific and Technological Research Council of Turkey (TÜBİTAK). The journal is dedicated to dissemination of knowledge in all disciplines of chemistry (organic, inorganic, physical, polymeric, technical, theoretical and analytical chemistry) as well as research at the interface with other sciences especially in chemical engineering where molecular aspects are key to the findings. The journal accepts English-language original manuscripts and contribution is open to researchers of all nationalities. The journal publishes refereed original papers, reviews, letters to editor and issues devoted to special fields. All manuscripts are peer-reviewed and electronic processing ensures accurate reproduction of text and data, plus publication times as short as possible.