1064 nm Nd: YAG激光对临床治疗真菌指甲感染抗真菌药物mic的影响

IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Taraneh Razavyoon, Seyed Jamal Hashemi, Parvin Mansouri, Roshanak Daie Ghazvini, Sadegh Khodavaisy, Heydar Bakhshi, Saham Ansari, Zahra Rafat, Nahid Nikkhah, Bahram Mohajer, Shayesteh Razavyoon, Davoud Roostaei
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Methods: Sixty onychomycosis samples consisting of saprophyte (n=20), dermatophyte (n=20), and yeast (n=20) duplicate colonies were isolated. A series was treated by a long-pulsed 1064-nm Nd: YAG laser. Afterward, the MIC (CLSI-M38-A2 and CLSI-M27-A3) of two series against common antifungals were compared. Results: After 1064-nm Nd: YAG laser irradiation in all 20 tested saprophytes, the MICs of terbinafine (P value<0.035) were changed, and in all 20 tested dermatophytes, the MICs of voriconazole (P value<0.021) were changed. Also, in all 20 tested yeasts, the MICs of caspofungin (P value<0.037) were changed. Moreover, in saprophytes, dermatophytes, and yeasts, significant changes in the MICs of itraconazole (P value<0.032), terbinafine (P value<0.025), and caspofungin (P value<0.037) were detected. Our result showed the GM MICs of the 1064-nm Nd: YAG laser in all saprophyte, dermatophyte, and yeast groups were lower than in the control group. 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引用次数: 0

摘要

指甲真菌感染(甲真菌病)占所有指甲疾病的18%-40%,虽然不是致命的,但可以引起机械、美学、职业和经济问题。药物治疗由于治疗时间延长、药物相互作用、不良反应和缓慢的进展可能与许多负面结果相关。本研究旨在评估长脉冲1064 nm Nd: YAG激光对真菌菌落的影响,以及与相同的非激光菌落相比,常见抗真菌药物的最低抑制浓度(mic)可能发生的变化,作为研究激光与抗真菌相互作用的新方法。方法:对60份甲真菌标本进行分离,其中包括腐生菌(n=20)、皮肤菌(n=20)和酵母菌(n=20)重复菌落。采用长脉冲1064 nm Nd: YAG激光处理。然后比较两个系列对常见抗真菌药物的MIC (CLSI-M38-A2和CLSI-M27-A3)。结果:1064 nm Nd: YAG激光照射20种腐生植物后,特比萘芬的mic均发生变化(P值为0.035),伏立康唑的mic均发生变化(P值为0.021)。此外,在所有20个被试酵母中,caspofungin的mic (P值<0.037)都发生了变化。此外,在腐生植物、皮肤植物和酵母中,检测到伊曲康唑(P值<0.032)、特比萘芬(P值<0.025)和卡泊芬素(P值<0.037)的mic有显著变化。结果表明,1064 nm Nd: YAG激光在腐生植物、皮肤植物和酵母菌组的转基因mic均低于对照组。结论:长脉冲1064 nm Nd: YAG激光可显著改变甲癣临床样品中抗真菌药物的mic。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of the 1064 nm Nd: YAG Laser on the MICs of Antifungals Used in Clinical Practice for the Treatment of Fungal Nail Infections
Introduction: The fungal nail infection (onychomycosis) involves 18%-40% of all nail disorders, which, although not fatal, can cause mechanical, aesthetic, occupational, and economic problems. Drug treatments due to prolonged treatment periods, drug interactions, adverse effects, and slow progression may associate with numerous negative outcomes. This study aimed to evaluate the long-pulsed 1064-nm Nd: YAG laser effect on fungal colonies and subsequently possible change in the minimum inhibitory concentrations (MICs) of common antifungals compared with the same non-lasered colonies as a novel way to investigate laser and antifungal interaction. Methods: Sixty onychomycosis samples consisting of saprophyte (n=20), dermatophyte (n=20), and yeast (n=20) duplicate colonies were isolated. A series was treated by a long-pulsed 1064-nm Nd: YAG laser. Afterward, the MIC (CLSI-M38-A2 and CLSI-M27-A3) of two series against common antifungals were compared. Results: After 1064-nm Nd: YAG laser irradiation in all 20 tested saprophytes, the MICs of terbinafine (P value<0.035) were changed, and in all 20 tested dermatophytes, the MICs of voriconazole (P value<0.021) were changed. Also, in all 20 tested yeasts, the MICs of caspofungin (P value<0.037) were changed. Moreover, in saprophytes, dermatophytes, and yeasts, significant changes in the MICs of itraconazole (P value<0.032), terbinafine (P value<0.025), and caspofungin (P value<0.037) were detected. Our result showed the GM MICs of the 1064-nm Nd: YAG laser in all saprophyte, dermatophyte, and yeast groups were lower than in the control group. Conclusion: The present study indicated that the long-pulsed 1064-nm Nd: YAG laser significantly changes the MICs of antifungals in onychomycosis clinical samples.
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来源期刊
Journal of lasers in medical sciences
Journal of lasers in medical sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
3.00
自引率
13.30%
发文量
24
期刊介绍: The "Journal of Lasers in Medical Sciences " is a scientific quarterly publication of the Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences. This journal received a scientific and research rank from the national medical publication committee. This Journal accepts original papers, review articles, case reports, brief reports, case series, photo assays, letters to the editor, and commentaries in the field of laser, or light in any fields of medicine such as the following medical specialties: -Dermatology -General and Vascular Surgery -Oncology -Cardiology -Dentistry -Urology -Rehabilitation -Ophthalmology -Otorhinolaryngology -Gynecology & Obstetrics -Internal Medicine -Orthopedics -Neurosurgery -Radiology -Pain Medicine (Algology) -Basic Sciences (Stem cell, Cellular and Molecular application and physic)
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