SYNTHESIS OF THREE COMPONENT (GO-CS/ZnO) NANOCOMPOSITE AND FORMULATION OFTHEIR NANO-OINTMENT FOR RAPID WOUND HEALING

: Implementation of nanotechnology with medicine offers extraordinary openings to synthesize materials at a nanoscale level. The healing of wound is still a demanding area for which an intelligent and efficient treatment is needed. Therefore the present findings have reported the significance of using GO-CS/ZnO based nanoointment on skin wound healing via in vivo investigations. The antibacterial activity of nanocomposite based nanoointment was evaluated by using gram positive Staphylococcus aureus MCCB 0227. The nanocomposites were synthesized and characterized by using X-ray diffraction, SEM, TEM & FTIR. The therapeutic effect of ointments comprising GO–CS/ZnO nanocomposite with different formulations as NO1 (0.1% GO), NO2 (0.1% GO-ZnO), NO3 (0.1% GO-CS) and NO4 (0.1% GO-CS/ZnO) were evaluated in vivo after the creation of wound over the dorsum of mice. As compared to positive control group (treated with marketed formulation gentamicin sulphate 0.1%), NO4 (GO-CS/ZnO) has an efficient antibacterial activity and potential effect on wound dressing and wound care.