醋酸目视检查子宫颈癌前病变的评价

Asma Begum, Mohammad Moshiour Rahman, Sumyia Akhter, Sharmin Afroz, Amena Begum
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摘要

背景:在孟加拉国,宫颈癌是一个主要的公共卫生问题,没有广泛的有组织的子宫颈筛查计划。宫颈醋酸目视检查(VIA)是一种高效、低成本的筛查试验,可与熟练卫生工作者提供的早期宫颈病变的简单治疗程序相结合。为了评估任何预防方案对宫颈癌发病率和死亡率的影响,必须充分覆盖25至50岁的妇女。根据对孟加拉国各种筛查程序费用的数学建模,VIA是一种节省成本的筛查方法。方法:随机来到BSMMU VIA中心的100名符合条件的女性接受了定义明确、不透明、靠近鳞状柱连接处或过渡区或宫颈溃疡增生性生长密集的醋酸白病变为VIA阳性。筛查试验结果异常及临床怀疑病变者行阴道镜检查,并在阴道镜怀疑区行定向活检。最终诊断基于组织学。结果:健康子宫颈11例(11%)疑似炎症4例(4%),CIN-I 58例(58%),CIN-II 14例(14%),CNN-III 10例(10%),浸润性癌3例(3%)。在100例活检患者中,81%发现宫颈上皮内瘤变,其中CIN占52.5%,CIN占17%,CIN占8.5%。浸润性癌占3%,炎症占4%。结论:在检测不同级别宫颈上皮内病变时,VIA与阴道镜检查同样有效。在这里,VIA适用于宫颈癌的诊断、随访和流行病学研究,也适用于低资源环境中癌前病变的检测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of Visual Inspection of Cervix with Acetic Acid in Detecting Precancerous Lesions
Background: Cervical cancer is a major public health problem in Bangladesh without widespread organized cervical screening programs. The acetic acid visual inspection of the cervix (VIA) is an efficient, low-cost screening test that can be paired with easy treatment procedures for early cervical lesions provided by skilled health workers. To evaluate the effect of any prevention program on cervical cancer incidence and mortality rates, women aged 25 to 50 must be adequately covered. VIA is a cost-saving method of screening, according to mathematical modeling of the expenses of various screening procedures in Bangladesh. Methods: Total 100 eligible woman who randomly came to the VIA centre of BSMMU were examined by VIA detection of well defined, opaque, acetowhite lesions close to the squamocolumner junction or in transitional zone or dense acetowhitening of ulcero proliferative growth on the cervix constitute a positive VIA Those who had abnormal results in screening test and those who had clinically suspicions lesion were sent for colposcopic evaluation and directed biopsy were taken from colposcopically suspected area. The final diagnosis was based on histology. Results: Healthy cervix was in 11 cases (11%) suspected inflammation was 4 cases (4%), CIN-I was 58 cases (58%), CIN-II was in 14 cases (14%), CNN-III was in 10 cases (10%), and invasive carcinoma was in 3 case (3%). Out of 100 patients biopsied, cervical intraepithelial neoplasia found among 81% cases of which CIN was in 52.5%, CIN II was in 17% and CIN III was in 8.5%. Invasive carcinoma found in 3% and inflammation was in 4% cases. Conclusion: VIA was as effective as colposcopy at detecting various grades of intraepithelial cervix lesions. Here, VIA was suitable for the diagnosis, follow-up care, and epidemiological research of cervical cancer, as well as for the detection of precancerous lesions in low resource settings.
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