{"title":"基于介孔二氧化锰和聚多巴胺的生物可降解药物控制输送系统","authors":"Miaomiao Li, Wenrong Cai, Lihua Jiang, Junyao Li, Shan Li, Tongtong Tang, Yong Kong","doi":"10.1002/bkcs.12788","DOIUrl":null,"url":null,"abstract":"<p>Mesoporous manganese dioxide (mMnO<sub>2</sub>) was first synthesized for the loading of methotrexate (MTX), and then dopamine was in situ polymerized on the surface of the MTX-loaded mMnO<sub>2</sub> (mMnO<sub>2</sub>-MTX) in an alkaline solution to encapsulate the drug in the mesopores of mMnO<sub>2</sub>. Both low pH and glutathione (GSH) can result in the degradation of mMnO<sub>2</sub> and poly(dopamine) (PDA), and thus the delivery of MTX from the mMnO<sub>2</sub>-MTX-PDA can be triggered by low pH and GSH. Near-infrared (NIR) light-responsive delivery of MTX can be achieved owing to the outstanding photothermal conversion capability of PDA; on the other hand, the mMnO<sub>2</sub>-MTX-PDA can be utilized for photothermal therapy under the irradiation of NIR light due to the elevated temperature. The results of cytotoxicity test demonstrate that the pH, GSH, and NIR light tri-responsive drug-controlled delivery system has excellent biocompatibility, while exhibits pronounced growth inhibition against murine breast tumor cell line 4T1.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A biodegradable drug-controlled delivery system based on mesoporous manganese dioxide and poly(dopamine)\",\"authors\":\"Miaomiao Li, Wenrong Cai, Lihua Jiang, Junyao Li, Shan Li, Tongtong Tang, Yong Kong\",\"doi\":\"10.1002/bkcs.12788\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Mesoporous manganese dioxide (mMnO<sub>2</sub>) was first synthesized for the loading of methotrexate (MTX), and then dopamine was in situ polymerized on the surface of the MTX-loaded mMnO<sub>2</sub> (mMnO<sub>2</sub>-MTX) in an alkaline solution to encapsulate the drug in the mesopores of mMnO<sub>2</sub>. Both low pH and glutathione (GSH) can result in the degradation of mMnO<sub>2</sub> and poly(dopamine) (PDA), and thus the delivery of MTX from the mMnO<sub>2</sub>-MTX-PDA can be triggered by low pH and GSH. Near-infrared (NIR) light-responsive delivery of MTX can be achieved owing to the outstanding photothermal conversion capability of PDA; on the other hand, the mMnO<sub>2</sub>-MTX-PDA can be utilized for photothermal therapy under the irradiation of NIR light due to the elevated temperature. The results of cytotoxicity test demonstrate that the pH, GSH, and NIR light tri-responsive drug-controlled delivery system has excellent biocompatibility, while exhibits pronounced growth inhibition against murine breast tumor cell line 4T1.</p>\",\"PeriodicalId\":54252,\"journal\":{\"name\":\"Bulletin of the Korean Chemical Society\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2023-10-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin of the Korean Chemical Society\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/bkcs.12788\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of the Korean Chemical Society","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bkcs.12788","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A biodegradable drug-controlled delivery system based on mesoporous manganese dioxide and poly(dopamine)
Mesoporous manganese dioxide (mMnO2) was first synthesized for the loading of methotrexate (MTX), and then dopamine was in situ polymerized on the surface of the MTX-loaded mMnO2 (mMnO2-MTX) in an alkaline solution to encapsulate the drug in the mesopores of mMnO2. Both low pH and glutathione (GSH) can result in the degradation of mMnO2 and poly(dopamine) (PDA), and thus the delivery of MTX from the mMnO2-MTX-PDA can be triggered by low pH and GSH. Near-infrared (NIR) light-responsive delivery of MTX can be achieved owing to the outstanding photothermal conversion capability of PDA; on the other hand, the mMnO2-MTX-PDA can be utilized for photothermal therapy under the irradiation of NIR light due to the elevated temperature. The results of cytotoxicity test demonstrate that the pH, GSH, and NIR light tri-responsive drug-controlled delivery system has excellent biocompatibility, while exhibits pronounced growth inhibition against murine breast tumor cell line 4T1.
期刊介绍：
The Bulletin of the Korean Chemical Society is an official research journal of the Korean Chemical Society. It was founded in 1980 and reaches out to the chemical community worldwide. It is strictly peer-reviewed and welcomes Accounts, Communications, Articles, and Notes written in English. The scope of the journal covers all major areas of chemistry: analytical chemistry, electrochemistry, industrial chemistry, inorganic chemistry, life-science chemistry, macromolecular chemistry, organic synthesis, non-synthetic organic chemistry, physical chemistry, and materials chemistry.
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