水芹的植物化学研究及其提取物和分离化合物的抗氧化活性

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Bulletin of the Chemical Society of Ethiopia Pub Date : 2023-09-25 DOI:10.4314/bcse.v37i6.14

Mohammedamin Nasir Isa, Wendimagegn Mammo, Estifanos Ele Yaya

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引用次数: 0

摘要

摘要在本研究中，试图从水芹(P. schimperi)干叶的溶剂提取物中分离出次生代谢物。分离得到6个化合物，分别为-8b、12-附二氧基-12b-羟基-9(11)、13-二烯-15-酸-g-内酯(1)、3,5,5,5 '-三羟基-6,7,3'，4'-四甲氧基黄酮(2)、3,5,7,5'-四羟基-6,3'，4'-三甲氧基黄酮(3)、对羟基肉桂酸(4)、木犀草素(5)和1-壬烷醇(6)，并通过NMR、UV-Vis、MS和FTIR等光谱技术进行了表征。所有的化合物;除木犀草素(5)外，均为首次报道。此外，通过GC-MS分析，共鉴定出47种化合物，其中a-姜黄烯(16.38%)、石竹烯(10.73%)、丁香酚(6.85%)、b-倍半黄烯(4.65%)、g-古芦烯(4.55%)、松油烯-4-醇(2.9%)、g-木犀草酚(4.43%)、芳樟醇(2.2%)和石竹烯氧化物(2.67%)为主要化合物。此外，利用DPPH法评估MeOH提取物和化合物1的抗氧化活性，在浓度为100 μg/mL时，DPPH抑制率分别为95.3%和62.2%。【关键词】香茅，GC-MS, DPPH自由基清除试验，抗氧化活性，乙酰化;公牛。化学。Soc。中国生物医学工程学报，2016,37(6)，1471-1486。DOI: https://dx.doi.org/10.4314/bcse.v37i6.14& x0D;

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Phytochemical studies of Premna schimperi, and antioxidant activities of the extract and an isolated compound

ABSTRACT. In this study, the attempts were made to isolate secondary metabolites from the solvent extract of the dried leaves of Premna schimperi (P. schimperi). Thus, six compounds, namely, ent-8b,12-epidioxy-12b-hydroxylabda-9(11),13-dien-15-oic acid-g-lactone (1), 3,5,5'-trihydroxy-6,7,3',4'-tetramethoxyflavone (2) and 3,5,7,5'-tetrahydroxy-6,3',4'-trimethoxyflavone (3), p-hydroxycinnamic acid (4), luteolin (5) and 1-nonacosanol (6) were isolated and characterized by NMR, UV-Vis, MS and FTIR spectroscopic techniques. All the compounds; except luteolin (5) were reported for the first time from the leaves of P. schimperi. In addition, the GC-MS analysis of the essential oil of the plant leaves revealed 47 compounds, of which a-curcumene (16.38%), caryophyllene (10.73%), eugenol (6.85%), b-sesquiphellandrene (4.65%), g-gurjunene (4.55%), terpinen-4-ol (2.9%), g-eudesmol (4.43%), linalool (2.2%) and caryophyllene oxide (2.67%) were the major compounds. Furthermore, assessment of the antioxidant activities of the MeOH extract and compound 1 using the DPPH assay revealed 95.3% and 62.2% DPPH inhibition, respectively, at concentration of 100 μg/mL. KEY WORDS: P. schimperi, GC-MS, DPPH radical scavenging assay, Antioxidant activity, Acetylation Bull. Chem. Soc. Ethiop. 2023, 37(6), 1471-1486.DOI: https://dx.doi.org/10.4314/bcse.v37i6.14

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来源期刊

Bulletin of the Chemical Society of Ethiopia 化学-化学综合

CiteScore

2.20

自引率

8.30%

发文量

113

审稿时长

6-12 weeks

期刊介绍： The Bulletin of the Chemical Society of Ethiopia (BCSE) is a triannual publication of the Chemical Society of Ethiopia. The BCSE is an open access and peer reviewed journal. The BCSE invites contributions in any field of basic and applied chemistry.