非酒精性脂肪性肝病(NAFLD):从组学角度的系统回顾和荟萃分析

Q2 Biochemistry, Genetics and Molecular Biology

Gene expression Pub Date : 2023-06-14 DOI:10.14218/ge.2023.00005

Luxita Sharma, Manoj Kumar Kashyap, Dhananjay Sharma

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引用次数: 0

摘要

背景和目的非酒精性脂肪性肝病(NAFLD)是发达国家最常见的慢性肝病，约占全球病例的24%，包括非酒精性脂肪性肝炎。NAFLD的特征是脂质积累而不是酒精消耗。NAFLD有几种诊断/预后生物标志物，包括CK-18、ALT、AST、GGT和触珠蛋白，但敏感性和特异性有限。因此，高通量组学方法已被用于表征NAFLD条件，以识别潜在的分子特征或差异调节分子(dem)和NAFLD的早期检测。

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Non-alcoholic Fatty Liver Disease (NAFLD): A Systematic Review and Meta-analysis from an Omics Perspective

Background and objectivesNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in developed countries, contributing to ∼24% of cases worldwide and includes non-alcoholic steatohepatitis. NAFLD is characterized by lipid accumulation rather than alcohol consumption. There are several diagnostic/prognostic biomarkers for NAFLD including CK-18, ALT, AST, GGT, and haptoglobin, but with limited sensitivity and specificity. Therefore, high-throughput OMICS approaches have been used to characterize NAFLD conditions for the identification of potential molecular signatures or differentially regulated molecules (DEMs) and early detection of NAFLD.

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来源期刊

Gene expression 生物-生物工程与应用微生物

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Gene Expression, The Journal of Liver Research will publish articles in all aspects of hepatology. Hepatology, as a research discipline, has seen unprecedented growth especially in the cellular and molecular mechanisms of hepatic health and disease, which continues to have a major impact on understanding liver development, stem cells, carcinogenesis, tissue engineering, injury, repair, regeneration, immunology, metabolism, fibrosis, and transplantation. Continued research and improved understanding in these areas will have a meaningful impact on liver disease prevention, diagnosis, and treatment. The existing journal Gene Expression has expanded its focus to become Gene Expression, The Journal of Liver Research to meet this growing demand. In its revised and expanded scope, the journal will publish high-impact original articles, reviews, short but complete articles, and special articles (editorials, commentaries, opinions) on all aspects of hepatology, making it a unique and invaluable resource for readers interested in this field. The expanded team, led by an Editor-in-Chief who is uniquely qualified and a renowned expert, along with a dynamic and functional editorial board, is determined to make this a premier journal in the field of hepatology.