金属纳米颗粒与细胞色素P450、丙氨酸转氨酶和天冬氨酸转氨酶的相互作用

IF 0.7 Q4 MICROBIOLOGY
Hayat A. Al-Btoush
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引用次数: 0

摘要

金属纳米粒子(NPs)在各种工业和生物医学领域的应用呈指数增长。因此,审查这些新粒子对人类健康潜在毒性影响的研究也在增加。细胞色素P450 (P450)酶在内源性和外源性分子代谢中起重要作用。抑制或诱导这些酶会影响外源性解毒,并导致临床显著的药物毒性或治疗失败。谷丙转氨酶(ALT)和天冬氨酸转氨酶(AST)是肝损伤最常用的生物标志物,其诱导程度是肝毒性的重要指标。本文综述了金属NPs对p450、ALT和AST(氨基转移酶)影响的相关文献。研究发现,金属NPs的主要作用是抑制cyp450基因和蛋白表达,诱导转氨酶,这突出了它们潜在的相互作用和诱导药物相关毒性以及肝毒性。然而,建议进一步研究NPs的大小,形态,表面积,电荷和NPs涂层对这些酶表达的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Interactions between Metallic Nanoparticles and Cytochrome P450, Alanine Aminotransferase, and Aspartate Aminotransferase Enzymes
The use of metallic nanoparticles (NPs) in various industrial and biomedical fields is increasing exponentially. As a result, research examining the potentially toxic impact of these NPs on human health is also increasing. Cytochrome P450 (P450s) enzymes are important for the endogenous and exogenous molecules metabolism. Inhibition or induction of these enzymes affects xenobiotic detoxification and causes clinically significant drug toxicity or therapeutic failures. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are the most frequently used biomarker for liver injury and their induction is an important indicator of hepatotoxicity. This review aims to understand the existing literature relevant to the effect of metallic NPs on P450s, ALT and AST (aminotransferases) enzymes. It was found that the predominant effect of metallic NPs is the inhibition of the CYP 450 gene and protein expression and induction of aminotransferases, which highlights their potential interaction and induction of drug-associated toxicity as well as their hepatotoxicity. However, further studies are recommended to investigate the effect of NPs size, morphology, surface area, charge, and NPs coating on the expression of these enzymes.
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来源期刊
Journal of Pure and Applied Microbiology
Journal of Pure and Applied Microbiology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MICROBIOLOGY
CiteScore
2.00
自引率
0.00%
发文量
266
审稿时长
11 months
期刊介绍: Journal of Pure and Applied Microbiology (JPAM) is a peer-reviewed, open access international journal of microbiology aims to advance and disseminate research among scientists, academics, clinicians and microbiologists around the world. JPAM publishes high-quality research in all aspects of microbiology in both online and print form on quarterly basis.
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