牙源性囊肿中的胆固醇结晶:发病机制的深入叙述

Sanpreet Singh Sachdev, Praveen Singh, Tabita Joy Chettiankandy, Akshay Trimukhe, Jyotsna Batra Sachdev, Anil Richhawal
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引用次数: 0

摘要

胆固醇结晶(CCs)是感染牙源性囊肿中相对常见的发现,约占60%的病例。组织病理学上表现为纵裂样间隙或胆固醇肉芽肿的集合。牙源性囊肿的发生与病变的病理生理密切相关。尽管相当普遍,但对胆固醇的来源、这些裂缝的形成机制、发病机制和临床意义知之甚少。本文的重点是描述CCs的内容、发病机制和临床意义。我们的综述以详细的方式描述了CCs的形成机制,并对该过程中涉及的一系列事件进行了图像描述。胆固醇肉芽肿的形成是红细胞和白细胞分解、壁内出血、血供和淋巴引流减少、缺氧条件、血管通透性增加、脂质巨噬细胞积聚和破裂以及异物反应的累积效应。cc是一种非常常见而又神秘的实体,深入了解其发病机制、性质和影响将是病理学家非常感兴趣的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cholesterol Crystals in Odontogenic Cysts: An In-Depth Narrative of Pathogenesis
Cholesterol crystals (CCs) are a relatively common finding in infected odontogenic cysts occurring in about 60% of the cases. Histopathologically, these appear as longitudinal cleft-like spaces or may appear as a collection in cholesterol granulomata. The occurrence of CCs in odontogenic cysts is closely associated with the pathophysiology of the lesions. Despite being fairly common, not much is known about the sources of cholesterol, the mechanism of formation of these clefts, their pathogenesis, and their clinical implications. The present article focuses on describing CCs with respect to their contents, pathogenesis, and clinical implications. Our review describes the mechanism of the formation of CCs in a detailed manner along with a pictorial depiction of the cascade of events involved in the process. The formation of cholesterol granulomata is a cumulative effect of the breakdown of erythrocytes and leukocytes, intramural hemorrhage, decreased blood supply and lymphatic drainage, hypoxic conditions, increased vascular permeability, accumulation and rupture of lipid-laden macrophages, and foreign body reaction. It would be of great interest to pathologists to have an in-depth understanding of the pathogenesis, nature, and implications of CCs, which are very common yet enigmatic entities.
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