RARß甲基化是治疗高级别胶质瘤的新的临床生物标志物

IF 0.4 4区医学 Q4 NEUROSCIENCES

Neurological Sciences and Neurophysiology Pub Date : 2023-01-01 DOI:10.4103/nsn.nsn_26_23

Cigdem Toprak, Emine Ikbal Atli, Rasime Kalkan

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引用次数: 0

摘要

背景:多种途径和细胞过程的失调有助于从低级别胶质瘤到高级别胶质瘤的癌变。肿瘤微环境的改变、表观遗传状态的改变和高度的突变异质性是胶质细胞肿瘤发生的关键因素。视黄酸(RA)控制着大脑的稳态、再生和发育。RA受体(RAR)基因甲基化已在不同类型的神经胶质肿瘤中得到证实。目的和目的:本研究评估RARß基因作为神经胶质瘤的潜在治疗靶点。材料与方法:以替莫唑胺治疗胶质瘤的疗效为基础，采用计算机方法比较靶向RARß基因的潜在药物。结果与结论:计算技术可用于识别药物介导的途径。这项计算机研究为RARB和针对RARB的胶质瘤治疗策略提供了希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Methylation of RARß is a New Clinical Biomarker for Treatment in Higher-grade Gliomas

A BSTRACT Background: The dysregulation of various pathways and cellular processes contributes to the carcinogenic transition from low-grade gliomas to high-grade gliomas. The altered tumor microenvironment, altered epigenetic state, and high mutation heterogeneity are critical factors in glial tumors. The morphogen retinoic acid (RA) controls the homeostasis, regeneration, and development of the brain. RA receptor (RAR) gene methylation has been shown in different types of glial tumors. Aims and Objectives: This study assessed the RARß gene as a potential therapeutic target in gliomas. Materials and Methods: Using in silico methods, potential drugs targeting the RARß gene were compared based on temozolomide’s effectiveness in treating gliomas. Results and Conclusion: Computational techniques can be used to identify drug-mediated pathways. This in silico study holds promise for RARB and RARB-targeted treatment strategies in gliomas.

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来源期刊

Neurological Sciences and Neurophysiology Neuroscience-Neurology

CiteScore

0.70

自引率

25.00%

发文量

审稿时长

26 weeks

期刊介绍： Neurological Sciences and Neurophysiology is the double blind peer-reviewed, open access, international publication organ of Turkish Society of Clinical Neurophysiology EEG-EMG. The journal is a quarterly publication, published in March, June, September and December and the publication language of the journal is English.