循环18-糖基水解酶蛋白几丁三酸苷酶-1与糖尿病肾病肾功能障碍和全身炎症相关

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL
Kuppuswami Jayashree, Gandhipuram Periyasamy Senthilkumar, Mehalingam Vadivelan, Sreejith Parameswaran
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引用次数: 0

摘要

Chitotriosidase-1 (CHIT-1)是巨噬细胞激活的标志物,最近被认为与2型糖尿病(T2DM)有关。然而,其在糖尿病肾病(DKD)发生和进展中的作用在最近的文献中很少讨论。材料和方法:在这项横断面探索性研究中,81名T2DM患者根据是否存在DKD被分为两组。评估了他们的人体测量、生化和病理特征。采用酶联免疫吸附试验(ELISA)测定血浆中循环CHIT-1浓度。结果:CHIT-1在糖尿病肾病患者中显著升高,与年龄和性别无关。尿蛋白-肌酐比值(uPCR)在多元线性回归模型中评估,与肾脏疾病的严重程度相关,与年龄、性别、糖尿病病程和胰岛素抵抗无关。CHIT-1正预测研究人群发生DKD的可能性(曲线下面积= 0.724,P <0.05)。糖尿病病程与uPCR呈正相关,与肾小球滤过率呈负相关。中性粒细胞-淋巴细胞比率在DKD患者中升高。这一公认的全身性炎症标志物与CHIT-1呈显著正相关。结论:DKD患者血浆CHIT-1蛋白升高并与疾病进展相关。它能够反映疾病的严重程度,与可能由促炎循环免疫细胞引起的全身性炎症密切相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Circulating 18-Glycosyl Hydrolase Protein Chitiotriosidase-1 is Associated with Renal Dysfunction and Systemic Inflammation in Diabetic Kidney Disease
Introduction: Chitotriosidase-1 (CHIT-1) is a marker of macrophage activation and recently attributed to type 2 diabetes mellitus (T2DM). However, its role in the development and progression of diabetic kidney disease (DKD) has been sparsely discussed in the recent literature. Materials and Methods: In this cross-sectional exploratory study, 81 participants with T2DM were classified into two groups based on the presence of DKD. Their anthropometric, biochemical, and pathological profiles were estimated. Circulatory CHIT-1 concentration was determined using the enzyme-linked immuno-sorbent assay (ELISA) in plasma. Results: CHIT-1 was significantly elevated in diabetic nephropathy, independent of age and gender. It is associated with severity of kidney disease, as assessed using urinary protein-creatinine ratio (uPCR) in a multiple linear regression model, independent of age, gender, diabetes duration, and insulin resistance. CHIT-1 positively predicted the likelihood of DKD in the study population (area under the curve = 0.724, P < 0.05). The duration of diabetes correlated positively with uPCR and negatively with estimated glomerular-filtration rate. Neutrophil-Lymphocyte ratio was elevated in participants with DKD. This well-established marker of systemic inflammation exhibited significant positive association with CHIT-1. Conclusion: Plasma CHIT-1 protein is elevated in DKD and associated with disease progression. It is capable of reflecting disease severity and is closely related to systemic inflammation possibly caused by pro-inflammatory circulatory immune cells.
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