壳聚糖在聚合物表面涂覆羟基磷灰石的研究

IF 0.5 Q4 ENGINEERING, BIOMEDICAL
Marwa Jamal Mohammed, Marwan N. Arbilei, Sadiq J. Hamandi, Hussein A. Hussein
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引用次数: 0

摘要

生物相容性骨植入物常被用于改善骨整合,如金属或聚合物。钙羟基磷灰石Ca 10 (po4) 6 -OH 2, HA是人体骨骼的主要无机成分。羟基磷灰石和聚合物与人体具有生物相容性,有助于促进骨骼生长。利用浸涂法在陶瓷材料上涂覆聚合物以增加骨整合本身就是一个挑战,因为使用先前的方法在陶瓷材料上涂覆聚合物的过程取得了成功。本研究旨在建立一种促进骨整合的新界面。聚合物部分和骨组织之间的界面克服了在被截肢者植入的金属肢体中出现的问题和失败。由于其被活体细胞排斥或植入物与接触部位之间缺乏良好的凝聚力。在这项工作中,PEEK塑料材料涂覆了一种活性生物相容性材料(羟基磷灰石)。植入骨内的聚合物部件将用作金属螺钉的锚,用于骨继承或假肢。本研究是用最简单、最有效的方法促进骨整合的一系列研究之一。根据壳聚糖材料的不同,采用浸渍法在陶瓷和聚合物(聚醚醚酮)之间形成粘合剂。胶带测试表明,HA和PEEK表面之间有良好的粘附性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Utilize Chitosan to Coat Hydroxyapatite on Polymer
Biocompatible bone implants are often proposed to improve osseointegration such as metal or polymer. Calcium hydroxyapatite Ca 10 (PO 4 ) 6 -OH 2 , HA is the primary inorganic component of human bone. Hydroxyapatite and polymer are biocompatible to the human body and help to increase bone growth. Increasing osseointegration by application of coating polymer on ceramic using the dip coating method is a challenge in itself for the success of the process of coating polymeric materials on ceramic materials using the previous method. This research aims to establish a new interface for promoting osseointegration. This interface between the polymeric part and the bone tissue to overcome the problems and failures that occur in the metal limbs implanted in the amputees. As a result of its rejection by the cells of the living body or the lack of good cohesion between the implant and the place of contact. In this work, coat PEEK plastic material coated with an active biocompatible material (Hydroxyapatite). The polymeric parts that implant inside the bone will be used as an anchor for the metallic screw that is used for bone succession or artificial limb. This research is one of a series of investigations that enhance bone osseointegration in the simplest and most efficient method. The dipping method is used to create adhesive between ceramic and polymer (polyether ether ketone) depending on the chitosan material. Tape tests showed that there was good adherence between the HA and PEEK surfaces.
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来源期刊
CiteScore
1.40
自引率
14.30%
发文量
73
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