体内容积法、DTI和1H MRS监测早期神经退行性变的大鼠脑方案及其治疗效果

IF 1 4区工程技术 Q4 INSTRUMENTS & INSTRUMENTATION

Measurement Science Review Pub Date : 2023-10-01 DOI:10.2478/msr-2023-0030

Tomáš Tvrdík, Ľubomír Melicherčík, Katarína Šebeková, Jakub Szabó, Marianna Maková, Daniel Gogola, Svatava Kašparová

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引用次数: 0

摘要

摘要:本研究的目的是为神经变性动物模型的体内成像和代谢参数(MRI, DTI和1h MRS)制定一种多模态实验方案。我们已经成功开发了同时进行DTI/MRI/ 1 H MRS测量的方案，以确保可重复的非侵入性实验的不变条件。本实验对d -半乳糖“年龄相关性痴呆”模型进行脑内弥散张量成像、光谱和体积“生物标志物”生成。海马相对体积、牛磺酸和肌醇相对浓度被发现是导致d -半乳糖治疗组大鼠在模拟“神经变性”中的差异的重要预测因素，即使是对应用石杉碱A治疗的反应。

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In vivo Volumetric, DTI and ¹H MRS Rat Brain Protocol for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

Abstract The aim of our study was to develop a multimodal experimental protocol for in vivo imaging and metabolic parameters (MRI, DTI and 1 H MRS) in an animal model of neurodegeneration. We have successfully developed the protocol for simultaneous DTI/MRI/ 1 H MRS measurement to ensure unaltered conditions for repeatable non-invasive experiments. In this experiment, diffusion tensor imaging, spectroscopic and volumetric “bio-markers” were generated in the brain for the D-galactose model of “age-related dementia”. The hippocampal relative volume, taurine and myo-inositol relative concentrations were found to be significant predictors contributing to the differences between the groups of rats treated with D-galactose in simulated “neurodegeneration”, even in response to the applied Huperzine A therapy.

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来源期刊

Measurement Science Review INSTRUMENTS & INSTRUMENTATION-

CiteScore

2.00

自引率

11.10%

发文量

审稿时长

4.8 months

期刊介绍： - theory of measurement - mathematical processing of measured data - measurement uncertainty minimisation - statistical methods in data evaluation and modelling - measurement as an interdisciplinary activity - measurement science in education - medical imaging methods, image processing - biosignal measurement, processing and analysis - model based biomeasurements - neural networks in biomeasurement - telemeasurement in biomedicine - measurement in nanomedicine - measurement of basic physical quantities - magnetic and electric fields measurements - measurement of geometrical and mechanical quantities - optical measuring methods - electromagnetic compatibility - measurement in material science