63岁男性房室分离异常表现及临床观察

Q4 Medicine

Journal of the Hong Kong College of Cardiology Pub Date : 2023-10-14 DOI:10.55503/2790-6744.1515

Yap-Hang Will Chan

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引用次数: 0

摘要

伊伐布雷定是一种特殊的有趣电流抑制剂，它阻断细胞内超极化激活的环核苷酸门控阳离子通道，并以使用依赖的方式导致舒张期去极化延迟。滑稽通道以前被认为只在窦房结内表达，最近发现它也在房室结和整个心肌中表达。这就提出了一个关键的临床问题，即伊伐布雷定的药理作用是否会超出其常规临床应用。

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Unusual Manifestation of Atrioventricular Dissociation in A 63 Year-Old Man and Clinical Insights

Ivabradine is a specific funny current inhibitor, which blocks Hyperpolarization-activated Cyclic Nucleotide-gated cation channels intra-cellularly and results in delayed diastolic depolarization in a use-dependent manner. Prior-believed to be exclusively expressed within the sinoatrial node, funny channels were recently revealed to be also expressed in the atrioventricular node and throughout the myocardium. These invite a key clinical question as whether pharmacological effects of ivabradine may extend beyond its conventional clinical use.

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来源期刊

Journal of the Hong Kong College of Cardiology Medicine-Cardiology and Cardiovascular Medicine

CiteScore

0.30

自引率

0.00%

发文量

期刊介绍： The Journal of the Hong Kong College of Cardiology publishes peer-reviewed articles on all aspects of cardiovascular disease, including original clinical studies, review articles and experimental investigations. As official journal of the Hong Kong College of Cardiology, the journal publishes abstracts of reports to be presented at the Scientific Sessions of the College as well as reports of the College-sponsored conferences.