HIV感染控制和病毒粒子抑制的最佳治疗方法

IF 8.8 3区医学 Q1 Medicine

Infectious Disease Modelling Pub Date : 2023-11-14 DOI:10.1016/j.idm.2023.11.006

Paolo Di Giamberardino, Daniela Iacoviello, Muhammad Zubair

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引用次数: 0

摘要

预防和早期诊断是战胜艾滋病毒的最佳和最有效的方法。目前还没有疫苗，但现在可以使用抗逆转录病毒药物治疗，在许多情况下，这些药物会使感染变成慢性感染。然而，研究强调了这些药物的副作用，以及如果停止治疗，感染会突然发作的事实。近年来，病毒储备存在于身体的各个部位，包括大脑，已经被假设。对控制健康细胞感染和阻断大脑内病毒粒子增殖的可能性进行了研究，提出了最佳控制策略。

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Optimal therapy for HIV infection containment and virions inhibition

Prevention and early diagnosis are the best and most effective ways for defeating HIV. There is still no vaccine, but treatments with antiretroviral drugs are now available which, in many cases, allow the infection to become chronic. However, research has highlighted side effects of these drugs and the fact that a flare-up of the infection occurs if the therapy is stopped. In recent years, the presence of virus reserves located in various parts of the body, including the brain, has been hypothesized. The possibility of controlling the infection of healthy cells and of interrupting the proliferation of virions inside the brain has been studied, proposing optimal control strategies.

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来源期刊

Infectious Disease Modelling Mathematics-Applied Mathematics

CiteScore

17.00

自引率

3.40%

发文量

审稿时长

17 weeks

期刊介绍： Infectious Disease Modelling is an open access journal that undergoes peer-review. Its main objective is to facilitate research that combines mathematical modelling, retrieval and analysis of infection disease data, and public health decision support. The journal actively encourages original research that improves this interface, as well as review articles that highlight innovative methodologies relevant to data collection, informatics, and policy making in the field of public health.