{"title":"类风湿关节炎患者IL-32和IL-37水平的评价","authors":"Raghda Hatem Omran, Zahra’a Abdul-Raheem Ahmed","doi":"10.21931/rb/css/2023.08.03.66","DOIUrl":null,"url":null,"abstract":"The present study aimed to evaluate the serum level of interleukins 32 and 37 (IL-32 and IL-37) in rheumatoid arthritis (RA) patients. An ELISA was used to measure the levels of cytokines in the blood of 56 RA patients and 44 healthy volunteers who were enrolled in the study from November 2021 to March 2022. Serum levels of IL-32 and IL-37 in the RA patients were significantly higher compared to the control groups (IL32, p = 0.035; IL37, p = 0.011). In addition, cytokine concentration levels were higher in RA patients under therapy than in RA patients with a first diagnosis and without therapy, with significant differences in IL-37(141.389 ± 24.133 vs. 58.852 ± 7.806 ng/L). In comparison, there were no significant differences in IL-32 (93.740 ± 10.835 vs. 76.722 ± 9.321 ng/L). The results suggest that pro-inflammatory and anti-inflammatory cytokines may play an essential role in the progression of RA. Keywords: Autoimmunity, IL-32, IL-37, Rheumatoid arthritis.","PeriodicalId":52287,"journal":{"name":"Revista Bionatura","volume":"10 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of IL-32 and IL-37 levels in Rheumatoid Arthritis\",\"authors\":\"Raghda Hatem Omran, Zahra’a Abdul-Raheem Ahmed\",\"doi\":\"10.21931/rb/css/2023.08.03.66\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The present study aimed to evaluate the serum level of interleukins 32 and 37 (IL-32 and IL-37) in rheumatoid arthritis (RA) patients. An ELISA was used to measure the levels of cytokines in the blood of 56 RA patients and 44 healthy volunteers who were enrolled in the study from November 2021 to March 2022. Serum levels of IL-32 and IL-37 in the RA patients were significantly higher compared to the control groups (IL32, p = 0.035; IL37, p = 0.011). In addition, cytokine concentration levels were higher in RA patients under therapy than in RA patients with a first diagnosis and without therapy, with significant differences in IL-37(141.389 ± 24.133 vs. 58.852 ± 7.806 ng/L). In comparison, there were no significant differences in IL-32 (93.740 ± 10.835 vs. 76.722 ± 9.321 ng/L). The results suggest that pro-inflammatory and anti-inflammatory cytokines may play an essential role in the progression of RA. Keywords: Autoimmunity, IL-32, IL-37, Rheumatoid arthritis.\",\"PeriodicalId\":52287,\"journal\":{\"name\":\"Revista Bionatura\",\"volume\":\"10 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-10-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Bionatura\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21931/rb/css/2023.08.03.66\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Bionatura","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21931/rb/css/2023.08.03.66","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
本研究旨在评价类风湿关节炎(RA)患者血清白细胞介素32和37 (IL-32和IL-37)水平。在2021年11月至2022年3月期间,研究人员使用ELISA来测量56名RA患者和44名健康志愿者血液中的细胞因子水平。RA患者血清IL-32、IL-37水平显著高于对照组(IL-32, p = 0.035;IL37, p = 0.011)。此外,接受治疗的RA患者的细胞因子浓度水平高于首次诊断和未接受治疗的RA患者,IL-37的差异具有统计学意义(141.389±24.133比58.852±7.806 ng/L)。相比之下,IL-32(93.740±10.835 vs. 76.722±9.321 ng/L)差异无统计学意义。结果提示,促炎和抗炎细胞因子可能在RA的进展中起重要作用。关键词:自身免疫,IL-32, IL-37,类风湿关节炎
Evaluation of IL-32 and IL-37 levels in Rheumatoid Arthritis
The present study aimed to evaluate the serum level of interleukins 32 and 37 (IL-32 and IL-37) in rheumatoid arthritis (RA) patients. An ELISA was used to measure the levels of cytokines in the blood of 56 RA patients and 44 healthy volunteers who were enrolled in the study from November 2021 to March 2022. Serum levels of IL-32 and IL-37 in the RA patients were significantly higher compared to the control groups (IL32, p = 0.035; IL37, p = 0.011). In addition, cytokine concentration levels were higher in RA patients under therapy than in RA patients with a first diagnosis and without therapy, with significant differences in IL-37(141.389 ± 24.133 vs. 58.852 ± 7.806 ng/L). In comparison, there were no significant differences in IL-32 (93.740 ± 10.835 vs. 76.722 ± 9.321 ng/L). The results suggest that pro-inflammatory and anti-inflammatory cytokines may play an essential role in the progression of RA. Keywords: Autoimmunity, IL-32, IL-37, Rheumatoid arthritis.