免疫营养状况(预后营养指数、中性粒细胞/淋巴细胞比率、血小板/淋巴细胞比率)对肝细胞癌患者经动脉化疗栓塞反应的影响

Eman helal, reham gameaa
{"title":"免疫营养状况(预后营养指数、中性粒细胞/淋巴细胞比率、血小板/淋巴细胞比率)对肝细胞癌患者经动脉化疗栓塞反应的影响","authors":"Eman helal, reham gameaa","doi":"10.21608/bmfj.2023.230162.1877","DOIUrl":null,"url":null,"abstract":": Background: Hepatocellular carcinoma (HCC) ranks as the fifth most common cancer worldwide. For individuals with intermediate-stage HCC, Transarterial chemoembolization (TACE) is a viable therapy option. So it is crucial to select patients to improve clinical outcomes in HCC patients after TACE. For patients with various cancers, immune health, including nutritional status and inflammatory state is essential. The prognostic nutritional index (PNI) is a multiparametric indicator that has been shown to accurately reflect patients' immune-inflammatory and nutritional status. The levels of neutrophil/lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) have been well-documented as systemic inflammation biomarkers that predict the prognosis of multiple neoplasms. Aim: This Study aimed to detect the impact of immuno-nutritional status in HCC patients treated with TACE. Patients and methods: Sixty patients with HCC who underwent TACE were enrolled and followed up in the Tropical Medicine Department, Tanta University. We excluded patients with prior locoregional therapy, systemic therapy and/or surgical intervention. At baseline and at 1& 3months post-procedure, laboratory criteria, tumor criteria were recorded, PNI, NLR PLR were calculated before TACE. Univariate and multivariate analyses were performed to identify factors affecting response to TACE. Results: Univariate analysis showed that high PNI, low NLR and low PLR were associated with a better response after TACE while multivariate analysis showed that only high PNI was an independent predictor of good response. Conclusion: Prognostic nutritional index can be used as baseline predictor of response before TACE.","PeriodicalId":8803,"journal":{"name":"Benha Veterinary Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of Immuno-nutritional status (prognostic nutritional index, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio) on response to Transarterial chemoembolization in Patients with Hepatocellular carcinoma\",\"authors\":\"Eman helal, reham gameaa\",\"doi\":\"10.21608/bmfj.2023.230162.1877\",\"DOIUrl\":null,\"url\":null,\"abstract\":\": Background: Hepatocellular carcinoma (HCC) ranks as the fifth most common cancer worldwide. For individuals with intermediate-stage HCC, Transarterial chemoembolization (TACE) is a viable therapy option. So it is crucial to select patients to improve clinical outcomes in HCC patients after TACE. For patients with various cancers, immune health, including nutritional status and inflammatory state is essential. The prognostic nutritional index (PNI) is a multiparametric indicator that has been shown to accurately reflect patients' immune-inflammatory and nutritional status. The levels of neutrophil/lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) have been well-documented as systemic inflammation biomarkers that predict the prognosis of multiple neoplasms. Aim: This Study aimed to detect the impact of immuno-nutritional status in HCC patients treated with TACE. Patients and methods: Sixty patients with HCC who underwent TACE were enrolled and followed up in the Tropical Medicine Department, Tanta University. We excluded patients with prior locoregional therapy, systemic therapy and/or surgical intervention. At baseline and at 1& 3months post-procedure, laboratory criteria, tumor criteria were recorded, PNI, NLR PLR were calculated before TACE. Univariate and multivariate analyses were performed to identify factors affecting response to TACE. Results: Univariate analysis showed that high PNI, low NLR and low PLR were associated with a better response after TACE while multivariate analysis showed that only high PNI was an independent predictor of good response. Conclusion: Prognostic nutritional index can be used as baseline predictor of response before TACE.\",\"PeriodicalId\":8803,\"journal\":{\"name\":\"Benha Veterinary Medical Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-11-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Benha Veterinary Medical Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21608/bmfj.2023.230162.1877\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Benha Veterinary Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/bmfj.2023.230162.1877","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of Immuno-nutritional status (prognostic nutritional index, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio) on response to Transarterial chemoembolization in Patients with Hepatocellular carcinoma
: Background: Hepatocellular carcinoma (HCC) ranks as the fifth most common cancer worldwide. For individuals with intermediate-stage HCC, Transarterial chemoembolization (TACE) is a viable therapy option. So it is crucial to select patients to improve clinical outcomes in HCC patients after TACE. For patients with various cancers, immune health, including nutritional status and inflammatory state is essential. The prognostic nutritional index (PNI) is a multiparametric indicator that has been shown to accurately reflect patients' immune-inflammatory and nutritional status. The levels of neutrophil/lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) have been well-documented as systemic inflammation biomarkers that predict the prognosis of multiple neoplasms. Aim: This Study aimed to detect the impact of immuno-nutritional status in HCC patients treated with TACE. Patients and methods: Sixty patients with HCC who underwent TACE were enrolled and followed up in the Tropical Medicine Department, Tanta University. We excluded patients with prior locoregional therapy, systemic therapy and/or surgical intervention. At baseline and at 1& 3months post-procedure, laboratory criteria, tumor criteria were recorded, PNI, NLR PLR were calculated before TACE. Univariate and multivariate analyses were performed to identify factors affecting response to TACE. Results: Univariate analysis showed that high PNI, low NLR and low PLR were associated with a better response after TACE while multivariate analysis showed that only high PNI was an independent predictor of good response. Conclusion: Prognostic nutritional index can be used as baseline predictor of response before TACE.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信