急性淋巴细胞白血病患者四次CAR-T细胞桥接两次同种异体造血干细胞移植治疗

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-08-22 DOI:10.1159/000531681

Qing Zhang, Yi Dong, Zhimin Zhai, Qianshan Tao

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引用次数: 0

摘要

& lt; b> & lt; i>简介:& lt; / i> & lt; / b>嵌合抗原受体T (CAR-T)细胞疗法是治疗复发或难治性急性淋巴细胞白血病(ALL)的同种异体造血干细胞移植(alloo - hsct)的有效桥接疗法。然而，由于技术上的困难以及患者的身体、经济和社会条件，重复CAR-T细胞治疗和同种异体造血干细胞移植只能在少数患者中进行。& lt; b> & lt; i>案例表示:& lt; / i> & lt; / b>一位23岁的女性b细胞ALL (B-ALL)二次复发患者接受了2次人鼠嵌合CD19 CAR-T细胞治疗，1次人鼠嵌合CD22 CAR-T细胞治疗，1次人源化CD19 CAR-T细胞治疗。此外，她先后接受了一次母亲的同种异体造血干细胞移植和一次表亲的同种异体造血干细胞移植。& lt; b> & lt; i>结论:& lt; / i> & lt; / b>对于复发或难治性ALL患者，重复CAR-T细胞治疗与重复同种异体造血干细胞移植的桥接仍然是一种安全而积极的治疗策略。

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Quartic CAR-T Cell Bridging to Twice Allo-HSCT Therapy in a Patient with Acute Lymphoblastic Leukemia

Introduction: Chimeric antigen receptor T (CAR-T) cell therapy is an effective bridging treatment for allogeneic hematopoietic stem cell transplantation (allo-HSCT) in relapsed or refractory acute lymphoblastic leukemia (ALL). However, repetitive CAR-T cell therapy and allo-HSCT can only be performed in a few patients because of technical difficulties and patients’ physical, economic, and social conditions. Case Presentation: A 23-year-old female patient with second relapsed B-cell ALL (B-ALL) underwent human-murine chimeric CD19 CAR-T cell therapy twice, human-murine chimeric CD22 CAR-T cell therapy once, and humanized CD19 CAR-T cell therapy once. Moreover, she was sequentially bridged to her mother donor allo-HSCT once and cousin donor allo-HSCT once. Conclusion: Repetitive CAR-T cell therapy bridging to repetitive allo-HSCT is still a safe and active therapeutic strategy for patients with relapsed or refractory ALL.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.