心血管磁共振在2min扫描时间内无创估计平均肺动脉压

Goran Abdula, Joao G Ramos, David Marlevi, Alexander Fyrdahl, Henrik Engblom, Peder Sörensson, Daniel Giese, Ning Jin, Andreas Sigfridsson, Martin Ugander
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引用次数: 1

摘要

【摘要】目的利用心血管磁共振(CMR)四维血流分析无创估计平均肺动脉压(mPAP)与有创右心导管术具有良好的一致性。然而,临床应用受到相对较长的扫描时间的限制。因此,本研究的目的是评估压缩感知(CS)加速采集用于mPAP估计的准确性和减少时间。方法和结果51例在1.5 T或3t行临床CMR的患者接受了原型cs加速和非cs加速血流序列的成像,获得了覆盖肺动脉的时间分辨率多重二维切片相对比三方向速度编码图像。原型软件用于肺动脉(PA)漩涡持续时间的盲法分析,以估计先前验证的mPAP。cs加速和非cs加速获得分别显示22/51(43%)和24/51(47%)患者的mPAP增加。两种方法估计mPAP的平均偏倚为0.1±1.9 mmHg,类内相关系数为0.97(95%可信区间0.94 ~ 0.98)。cs加速采集的有效扫描时间较低(1 min 55 s±27 s vs. 9 min 6 s±2 min 20 s), P <0.001,减少79%)。与非cs加速序列相比,cs加速CMR采集能够保持估计mPAP的准确性,允许平均扫描时间小于2分钟。因此cs加速增加了CMR 4D血流分析估计mPAP的临床实用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Non-invasive estimation of mean pulmonary artery pressure by cardiovascular magnetic resonance in under 2 min scan time
Abstract Aims Non-invasive estimation of mean pulmonary artery pressure (mPAP) by cardiovascular magnetic resonance (CMR) four-dimensional (4D) flow analysis has shown excellent agreement with invasive right heart catheterization. However, clinical application is limited by relatively long scan times. Therefore, the aim of this study was to evaluate the accuracy and time reduction of compressed sensing (CS) accelerated acquisition for mPAP estimation. Methods and results Patients (n = 51) referred for clinical CMR at 1.5 T or 3 T underwent imaging with both a prototype CS-accelerated and a non-CS-accelerated flow sequence acquiring time-resolved multiple 2D slice phase-contrast three-directional velocity-encoded images covering the pulmonary artery. Prototype software was used for the blinded analysis of pulmonary artery (PA) vortex duration to estimate mPAP as previously validated. CS-accelerated and non-CS-accelerated acquisition showed increased mPAP in 22/51 (43%) and 24/51 (47%) patients, respectively. The mean bias for estimating mPAP between the two methods was 0.1 ± 1.9 mmHg and the intraclass correlation coefficient was 0.97 (95% confidence interval 0.94–0.98). Effective scan time was lower for the CS-accelerated acquisition (1 min 55 s ± 27 s vs. 9 min 6 s ± 2 min 20 s, P &lt; 0.001, 79% reduction). Conclusions CS-accelerated CMR acquisition enables preserved accuracy for estimating mPAP compared to a non-CS-accelerated sequence, allowing for an average scan time of less than 2 min. CS-acceleration thereby increases the clinical utility of CMR 4D flow analysis to estimate mPAP.
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