以香油为亲脂载体制备双氯芬酸凝胶的研究

IF 0.6 4区医学 Q4 PHARMACOLOGY & PHARMACY

Tropical Journal of Pharmaceutical Research Pub Date : 2023-11-06 DOI:10.4314/tjpr.v22i10.1

Zwanden Sule Yahaya, Latifat Oyiza Otaru, Boma Blessing Mohammed, Olutayo Ademola Adeleye, Na'anman Charles Dagogot, Idris Abdullahi

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引用次数: 0

摘要

目的:考察芝麻油作为双氯芬酸乳状剂油相的适宜性。方法:制备由不同比例的油(芝麻油和/或Labrafac CC)、表面活性剂(Tween-80和/或cremophor EL-30)和胶凝剂(黄原胶或明胶)组成的不同批次的凝胶。对配方进行了流变性、协同作用、傅里叶变换红外光谱(FTIR)、铺展性、挤压性和抗炎活性的评价。结果:A2、A4、A6批的产品特性与乳剂不一致。由于A1批次表现出最稳定的特性，如没有pH变化，粘度结果变化无统计学意义(p = 1.000)， FTIR调查后光谱变化最小，因此被选为最佳批次。与市售双氯芬酸乳液相比，它显示出类似的抗炎活性，比双氯芬酸水分散液的抗炎效果高50%。& # x0D;结论:芝麻油是一种潜在的亲脂性成分，可用于局部递送疏水药物的凝胶制剂。

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Evaluation of diclofenac emulgel prepared with sesame oil as a lipophilic carrier

Purpose: To investigate the suitability of sesame oil as an oily phase for diclofenac emulgel formulation. Methods: Different batches of emulgel comprising different proportions of oils (sesame oil and/or Labrafac CC), surfactants (Tween-80 and/or cremophor EL-30), and gelling agents (xanthan gum or gelatin) were prepared. The formulations were evaluated for rheology, syneresis, Fourier transform infrared (FTIR) spectroscopy, spreadability, extrudability, and anti-inflammatory activity. Results: Product characteristics of batches A2, A4, and A6 were not consistent with those of emulgels. Because Batch A1 showed characteristics that were the most stable, such as no pH changes, nonstatistically significant changes (p = 1.000) in the viscosity results, and least spectrum changes following FTIR investigation, it was selected as the best batch. It showed similar anti-inflammatory activity when compared with commercially available diclofenac emulgel, giving a 50 % higher anti-inflammatory effect than aqueous diclofenac dispersion. Conclusion: Sesame oil is a potential lipophilic component in emulgel formulations for topical delivery of hydrophobic drugs.

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来源期刊

Tropical Journal of Pharmaceutical Research 医学-药学

CiteScore

1.00

自引率

33.30%

发文量

490

审稿时长

4-8 weeks

期刊介绍： We seek to encourage pharmaceutical and allied research of tropical and international relevance and to foster multidisciplinary research and collaboration among scientists, the pharmaceutical industry and the healthcare professionals. We publish articles in pharmaceutical sciences and related disciplines (including biotechnology, cell and molecular biology, drug utilization including adverse drug events, medical and other life sciences, and related engineering fields). Although primarily devoted to original research papers, we welcome reviews on current topics of special interest and relevance.