Nectin-3和Nectin-4:癌症靶向治疗的潜在预后生物标志物

IF 0.6 4区医学 Q4 PHARMACOLOGY & PHARMACY

Tropical Journal of Pharmaceutical Research Pub Date : 2023-11-06 DOI:10.4314/tjpr.v22i10.27

Aihong Yang, Yan Ge, Panpan Yang, Yuqi Xin, Chenlu Zhang, Feixue Xu, Jiao Yang

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引用次数: 0

摘要

Nectin-3和nectin-4属于免疫球蛋白(Ig)超家族，是不依赖于Ca2+的亲同性细胞粘附分子。Nectin-3在成人组织中普遍存在，它能促进正常水平的突触形成。相反，nectin-4在正常人体组织中弱至中度表达。近年来的研究表明，nectin-3在神经系统中高度表达。此外，在胰腺癌、肺癌和乳腺癌等远处转移瘤和血管高度浸润的恶性肿瘤中，它与预后不良因素有关。特别是nectin-4在多种恶性肿瘤中过表达，与增殖、血管生成、转移、耐药、肿瘤复发、DNA修复、肿瘤干细胞、预后不良等相关。与nectin-3不同，nectin-4已成为潜在的预后生物标志物和癌症的特异性治疗靶点，因为对各种癌症中nectin-3异常表达的意义尚未达成共识。

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Nectin-3 and Nectin-4: potential prognostic biomarkers for therapeutic targeting of cancer

Nectin-3 and nectin-4 belong to the immunoglobulin (Ig) superfamily, and are Ca2+ -independent homophilic cell adhesion molecules. Nectin-3 is ubiquitous in adult tissues, and it enhances normal levels of synaptic formation. In contrast, nectin-4 is weakly-to-moderately expressed in normal human tissues. In recent years, studies have shown that nectin-3 is highly expressed in the nervous system. Moreover, it is associated with poor prognostic factors in distant metastases and malignant tumors with high vascular invasion such as pancreatic, lung and breast cancers. In particular, nectin-4 is overexpressed in various malignant tumors, and it is associated with proliferation, angiogenesis, metastasis, drug resistance, tumor relapse, DNA repair, cancer stemness, and poor prognosis. Unlike nectin-3, nectin-4 has become a potential prognostic biomarker and specific therapeutic target for cancer as there is no consensus on the significance of abnormal expression of nectin-3 in various cancers.

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来源期刊

Tropical Journal of Pharmaceutical Research 医学-药学

CiteScore

1.00

自引率

33.30%

发文量

490

审稿时长

4-8 weeks

期刊介绍： We seek to encourage pharmaceutical and allied research of tropical and international relevance and to foster multidisciplinary research and collaboration among scientists, the pharmaceutical industry and the healthcare professionals. We publish articles in pharmaceutical sciences and related disciplines (including biotechnology, cell and molecular biology, drug utilization including adverse drug events, medical and other life sciences, and related engineering fields). Although primarily devoted to original research papers, we welcome reviews on current topics of special interest and relevance.