莫西沙星与抗糖尿病药物相互作用研究及反相高效液相色谱分析应用

IF 0.8 4区医学 Q3 EDUCATION, SCIENTIFIC DISCIPLINES

Indian Journal of Pharmaceutical Education and Research Pub Date : 2023-10-04 DOI:10.5530/ijper.57.4.146

Sania Bashir, Fatima Qamar, Safila Naveed, Syeda Zainab, Halima Sadia, Aisha Sana, Wajeeha Muzafar

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引用次数: 0

摘要

摘要:目的:建立同时测定制剂中格列美脲、格列本脲和莫西沙星含量的简便反相高效液相色谱法。材料与方法:采用尺寸为150mm×4.6mm的Mediterranean C18色谱柱，采用HPLC Shimadzu_ LC-20 AT模型，版本1:62在室温(25±2℃)下进行色谱处理。流速为1ml / min，检测器设置为254nm，流动相为85:10:5 v/v甲醇:水:乙腈。结果:所建立的方法准确、简便、有效、精密度高、重复性好。采用单因素方差分析进一步证实结果。结论:该方法适用于原料药和制剂中药物的常规分析及体外相互作用研究。关键词:莫西沙星，格列美脲，格列本脲，体外相互作用研究

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Interaction Studies of Moxifloxacin with Anti-diabetic Drugs and Application of RP-HPLC in Analysis

Abstract: Aim: Simple RP-HPLC method was developed and validated for the simultaneous estimation of Glimepiride, Glibenclamide and Moxifloxacin in pharmaceutical preparation. Materials and Methods: Mediterranean C18 column with dimensions of 150mm×4.6mm was used with HPLC Shimadzu_ LC-20 AT model, Version 1:62 is used for processing of chromatograms at room temperature (25± 2°C). 1 mL per minute was the flow rate and detector were set at 254nm with mobile Phase consisting of 85:10:5 v/v methanol: water: acetonitrile. Results: The developed method proved to be accurate, simple, effective precise and reproducible. One way ANOVA was also applied for further confirmation of the results. Conclusion: The method is applicable for the routine analysis of drugs in API and in formulation and for studying in vitro interaction studies. Keywords: Moxifloxacin, Glimepiride, Glibenclamide, in vitro interaction studies

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来源期刊

Indian Journal of Pharmaceutical Education and Research 医学-学科教育

CiteScore

1.40

自引率

0.00%

发文量

227

审稿时长

>12 weeks

期刊介绍： The official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967. IJPER, a quarterly publication devoted to publish reviews and research articles in pharmacy and the related disciplines of Pharmaceutical education. It mainly covers the articles of special interest, covering the areas of Pharmaceutical research, teaching and learning, laboratory innovations, education technology, curriculum design, examination reforms, training and other related issues. It encourages debates and discussions on the issues of vital importance to Pharmaceutical education and research. The goal of the journal is to provide the quality publications and publish most important research and review articles in the field of drug development and pharmaceutical education. It is circulated and referred by more than 6000 teachers, 40,000 students and over 1000 professionals working in Pharmaceutical industries, Regulatory departments, hospitals etc.