硝酸异山梨酯口腔崩解膜环糊精/HPMC:机械、光学和物理化学研究

IF 1 4区生物学 Q3 BIOLOGY

Brazilian Archives of Biology and Technology Pub Date : 2023-01-01 DOI:10.1590/1678-4324-2023220370

Larissa Lea da Silva, Marcelo Dutra Duque, Michele Georges Issa, Leticia Norma Carpentieri Rodrigues

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引用次数: 0

摘要

采用溶剂铸造法制备了环糊精/HPMC基口服膜。采用32因子设计制备ISDN口服给药膜。对其机械、光学和溶解性能进行了评价。实验设计对配方进行了优化。通过期望函数得到最佳配方。

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Isosorbide Dinitrate Orally Disintegrating Films Cyclodextrins/HPMC Based: Mechanical, Optical, and Physicochemical Studies

HIGHLIGHTS Orally films Cyclodextrins/HPMC based films were prepared by solvent casting. Films for oral delivery of ISDN were prepared by 32 factorial designs. Mechanical, optical, and dissolution properties were evaluated. The experimental design allowed to optimize the formulations. The best formulation was obtained by means of the desirability function.

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来源期刊

Brazilian Archives of Biology and Technology 生物-生物学

CiteScore

1.80

自引率

0.00%

发文量

116

审稿时长

3 months

期刊介绍： Information not localized