丙戊酸与短时间运动对妊娠小鼠脑源性神经营养因子的影响

IF 0.4 4区综合性期刊 Q4 ECOLOGY

Interciencia Pub Date : 2023-01-01 DOI:10.59671/4govc

Arni K.Dewi, None Widjiati, Bambang Purwanto, Dean Chou

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引用次数: 0

摘要

背景。大约50%的妇女在怀孕前有精神症状。他们的余生都在吸毒。药物是丙戊酸。在怀孕期间服用这种药物会导致神经发育障碍，如自闭症谱系障碍(ASD)。脑源性神经生长因子(BDNF)在神经系统发育中起重要作用。妊娠期血清中丙戊酸的升高和孕期运动可引起BDNF水平的降低。目标本研究旨在研究丙戊酸暴露妊娠小鼠血清BDNF水平，并探讨短时间内两种运动状态下BDNF水平与不运动的关系。研究母亲BDNF水平是否为ASD患儿更好的标记危险因素是很重要的。方法。孕鼠分为4组(对照组/1、运动组/ 2、丙戊酸组/ 3、运动组/4)。丙戊酸500 mg/ kg单次给药，孕16 d，连续运动4 d。检测血清BDNF母。结果。统计学上各组差异无统计学意义(p> 0.05)。但两种丙戊酸组的平均值均较对照组相对降低。运动不会改变水平，结论。由此可见，丙戊酸的摄入改变了产前BDNF分泌的生理机能，这可能是导致神经发育障碍的原因。

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Level of Brain Derived Neurotrophic Factor in pregnant Mice induced by Valproic Acid and Exercise in short time

Backgroud. About 50 percent woman had psychiatry symptom before pregnant. They had consumed drug for the rest life. The drug was valproic acid. Consumtion this drug during pregnancy would made neurodevelopmental disorder like Autism Spectrum Disorder (ASD). Brain Derived Neurothropic Factor (BDNF) have a role in development of Nervous system dams. The serum level increase during pregnancy and exercise Valproid acid which is consumed in pregnant may cause the decrease of BDNF level. Aims. Our study aims to investigate serum level of pregnant mice exposed to valproic acid and to investigate relationship level of BDNF with two condition exercise or not in short time. It is important to study to know, if BDNF level of mother is the better marker risk factor born child with ASD. Method. Pregnant mice differed into 4 group (control/1, control with exercise/ 2, valproid acid / 3, valproid acid with exercise /4). Valproic acid 500 mg/weight single dose was given at 16 days pregnant continue exercise for 4 days. Serum BDNF mother was examined. Result. Statistically, All groups had no significant value (p>0,05). But mean of both valproid acid groups, relatively decreased than control group. Exercise did not change the level.Conclusion. It could be concluded that consumtion of valproic acid could changed physiology of secretion of BDNF during prenatal, this is may be the causa of neurodevelopmental Disorder.

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来源期刊

Interciencia 综合性期刊-生态学

CiteScore

0.80

自引率

25.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Interciencia is the monthly multidisciplinary publication of the INTERCIENCIA Association. It is dedicated to stimulate scientific research, its humanitarian use and the study of its social context, specially in Latin America and the Caribbean and to promote communication between the scientific and technological communities of the Americas. Interciencia has been published uninterruptedly since 1976. Its Founding Director, Marcel Roche (endocrinologist and sociologist of science) was editor until 2008, and thereafter Miguel Laufer (neurobiologist) has been in charge. It has been included since 1978 in the Science Citation Index and other international indexes, and since 2008 it maintains an open access electronic version with material from 2005 onwards. The priority areas of the journal, without exclusion of other areas, are Agronomy, Arid Lands, Food and Nutrition, Biotechnology, Ecology and Environment, Energy, Innovation and Technology Transfer, Marine Resources, Non-renewable Resources, Science Education, Science Policy, Study and Sociology of Science, and Tropical Forests. Interciencia publishes in Spanish, Portuguese and English research and review articles, communications and essays, all of which are subjected to peer review. Additionally, it includes non-refereed sections such as Editorial, Letters to the Editor, Open Town Hall, Book Reviews and Upcoming Events. All the material submitted to the journal for publication and accepted by the Editorial Committee in view of its quality and pertinence is subjected to review by peer specialists in the corresponding fields of knowledge. Neither the INTERCIENCIA Association, nor the journal or the institutions to which the authors belong carry responsibility for the contents. Signing authors are responsible for the material published under their names.