亚诺马米和图纳普科微生物组的重金属抗性

IF 2.5 4区 医学 Q2 PARASITOLOGY
Liliane Costa Conteville, Joseli Oliveira-Ferreira, Ana Carolina P Vicente
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引用次数: 0

摘要

亚马逊地区拥有宝贵而独特的生物多样性以及矿产资源。因此,在土著领土上存在着大规模的非法和手工金矿。汞被用于金矿开采,一些汞被释放到环境和大气中,主要影响到雅诺马米族等土著居民。此外,其他重金属也与该区域的金矿开采和其他金属分散活动有关。目的研究亚马孙地区两个半分离群体的肠道微生物组,重点研究金属耐药性。方法将雅诺玛米和图纳普科肠道微生物组的宏基因组数据组装成contigs,并在金属抗性蛋白数据库中检索其推定的蛋白质。发现与汞抗性相关的蛋白在亚诺马米中是排他性的,而与银抗性相关的蛋白在图纳普科中是排他性的。两组共有77个非冗余金属抗性(MR)蛋白,主要与多MR和操纵子相关,具有对砷、镍、锌、铜、铜/银和钴/镍的潜在抗性。虽然两组都有与铜抗性有关的操纵子,但只有Tunapuco组有pco操纵子。结论:亚诺马米人和图纳普科人的肠道微生物组表明,这些人直接或间接暴露于不同的重金属环境中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Heavy metal resistance in the Yanomami and Tunapuco microbiome
BACKGROUND The Amazon Region hosts invaluable and unique biodiversity as well as mineral resources. Consequently, large illegal and artisanal gold mining areas exist in indigenous territories. Mercury has been used in gold mining, and some has been released into the environment and atmosphere, primarily affecting indigenous people such as the Yanomami. In addition, other heavy metals have been associated with gold mining and other metal-dispersing activities in the region. OBJECTIVE Investigate the gut microbiome of two semi-isolated groups from the Amazon, focusing on metal resistance. METHODS Metagenomic data from the Yanomami and Tunapuco gut microbiome were assembled into contigs, and their putative proteins were searched against a database of metal resistance proteins. FINDINGS Proteins associated with mercury resistance were exclusive in the Yanomami, while proteins associated with silver resistance were exclusive in the Tunapuco. Both groups share 77 non-redundant metal resistance (MR) proteins, mostly associated with multi-MR and operons with potential resistance to arsenic, nickel, zinc, copper, copper/silver, and cobalt/nickel. Although both groups harbour operons related to copper resistance, only the Tunapuco group had the pco operon. CONCLUSION The Yanomami and Tunapuco gut microbiome shows that these people have been exposed directly or indirectly to distinct scenarios concerning heavy metals.
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来源期刊
CiteScore
5.00
自引率
3.60%
发文量
91
审稿时长
3-8 weeks
期刊介绍: Memórias do Instituto Oswaldo Cruz is a journal specialized in microbes & their vectors causing human infections. This means that we accept manuscripts covering multidisciplinary approaches and findings in the basic aspects of infectious diseases, e.g. basic in research in prokariotes, eukaryotes, and/or virus. Articles must clearly show what is the main question to be answered, the hypothesis raised, and the contribution given by the study. Priority is given to manuscripts reporting novel mechanisms and general findings concerning the biology of human infectious prokariotes, eukariotes or virus. Papers reporting innovative methods for diagnostics or that advance the basic research with these infectious agents are also welcome. It is important to mention what we do not publish: veterinary infectious agents research, taxonomic analysis and re-description of species, epidemiological studies or surveys or case reports and data re-analysis. Manuscripts that fall in these cases or that are considered of low priority by the journal editorial board, will be returned to the author(s) for submission to another journal.
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