棘囊酸在阿尔茨海默病样病理中的作用的计算机和药代动力学评价

IF 2.4 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Future Science OA Pub Date : 2023-10-04 DOI:10.2144/fsoa-2023-0150

Ankul Singh S, Chitra Vellapandian

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引用次数: 0

摘要

目的:阿尔茨海默病导致痴呆，损害认知领域。方法:采用计算机或计算方法，包括pkCSM、Swiss ADME、OSIRIS®属性浏览器、PASS在线网络资源和MOLINSPIRATION®软件，预测棘囊酸的药代动力学特性和生物活性。结果,讨论:该化合物具有调节脂质代谢的特性，在减缓阿尔茨海默病的进展中起主要作用，且无重大副作用和不良反应。该药还具有抗炎特性，可以帮助调节先天免疫，而先天免疫在阿尔茨海默病中起着重要作用。结论:通过计算筛选，我们推断棘囊酸可以调节记忆丧失、认知功能障碍，并减缓阿尔茨海默病样病理进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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In silico and pharmacokinetic assessment of echinocystic acid effectiveness in Alzheimer's disease like pathology

Aim: Alzheimer's disease causes dementia which impairs the cognitive domains. Methodology: The pharmacokinetic characteristics and biological activity of echinocystic acid are predicted in this work using in silico or computational approaches, including pkCSM, Swiss ADME, OSIRIS ® property explorer, PASS online web resource and MOLINSPIRATION ® software. Results & discussion: The compound has lipid metabolism regulating property as major role in decreasing the progression of Alzheimer's disease and it has no major side effects and ADR. The drug also has anti-inflammatory properties which can help in regulating the innate immunity that plays a major role in Alzheimer's disease. Conclusion: From the computational screening, we infer that, echinocystic acid can regulate memory loss, cognitive disability and also slow down the progression of Alzheimer's disease-like pathology.

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来源期刊

Future Science OA MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.00

自引率

4.00%

发文量

审稿时长

13 weeks

期刊介绍： Future Science OA is an online, open access, peer-reviewed title from the Future Science Group. The journal covers research and discussion related to advances in biotechnology, medicine and health. The journal embraces the importance of publishing all good-quality research with the potential to further the progress of research in these fields. All original research articles will be considered that are within the journal''s scope, and have been conducted with scientific rigour and research integrity. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis. Submissions of the following article types will be considered: -Research articles -Preliminary communications -Short communications -Methodologies -Trial design articles -Trial results (including early-phase and negative studies) -Reviews -Perspectives -Commentaries