The potential role of Helicobacter pylori and other gut dysbiosis factors in the development of rosacea

Rosacea is a chronic inflammatory disease that presents with erythema, telangiectasia, papules, or pustules. Its mechanism of onset still needs to be fully understood. There has been an increasing number of studies and reports confirming the beneficial influence of eradication of Helicobacter pylori on the course of the disease. It has been recognized that the bacterium leads to the activation of the inflammatory immune response, resulting in the induction of symptoms similar to rosacea. Another thesis suggests a close connection between the gut–brain–skin axis, which relates to the influence of normal microbiota and gut health, and dermatological diseases. Correlations have been noted between the increased incidence of Crohn’s disease, ulcerative colitis, and irritable bowel syndrome in patients with rosacea.