靠近养猪场是嗜酸性食管炎的危险因素

Cary C. Cotton, Elizabeth T. Jensen, Kate Hoffman, Daniel J. Green, Amanda L. Tapia, Kevin O. Turner, Robert M. Genta, Evan S. Dellon
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引用次数: 0

摘要

我们的目的是通过使用两个互补的数据来源进行病例-对照研究,确定住所靠近允许养猪场是否与嗜酸性粒细胞性食管炎(EoE)的风险增加有关:一个来自第三级保健中心(n = 401例和1805例对照),另一个来自大型病理组(n = 904例和4074例对照)。研究对象和养猪场的地址进行了地理编码,并计算了与养猪场的接近度和密度相关的EoE调整几率。我们观察到靠近许可养猪场(1英里)与EoE几率呈正相关(调整优势比R, 2.56;95% CI, 1.33-4.95);农场密度(10个农场/人口普查区)也正相关(调整后优势比为2.76;95% ci, 1.30-5.84)。然而,在病理数据库中没有观察到这种关联。虽然猪场的邻近度和密度与EoE相关,但这种关联对所使用的数据库很敏感。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Proximity to Swine Farming Operations as a Risk Factor for Eosinophilic Esophagitis
We aimed to determine whether residential proximity to permitted swine facilities was associated with an increased risk of eosinophilic esophagitis (EoE) by conducting a case-control study using 2 complementary data sources: 1 from a tertiary care center (n = 401 cases and 1805 controls) and 1 from a large pathology group (n = 904 cases and 4074 controls). Addresses of the subjects and swine facilities were geocoded, and adjusted odds of EoE relative to proximity to and density of swine facilities were calculated. We observed a positive association between proximity to a permitted swine facility (<1 mile) and odds of EoE (adjusted odds ratio R, 2.56; 95% CI, 1.33–4.95) in the tertiary center data; density of farms (>10 farms/census tract) was also positively associated (adjusted odds ratio, 2.76; 95% CI, 1.30–5.84). However, this association was not observed in the pathology database. Though proximity to and density of swine operations were associated with EoE, associations were sensitive to the database used.
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