孕酮治疗通过调节miR-320b及其靶基因MCL1的表达来减弱子宫内膜息肉(EP)的增殖

IF 3 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Archives of Medical Science Pub Date : 2023-11-07 DOI:10.5114/aoms/171308

Yan Su, Weiwei Feng, Haofan Shi

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Treatment with progesterone attenuates proliferation of endometrial polyps (EP) via regulation of expression of miR-320b and its target gene, MCL1

The mechanism underlying the pathogenesis of endometrial polyps (EP) remains unclear. Endocrinopathy can be corrected by counteracting the effect of oestrogenic stimulation with progesterone, and systemic administration of pregestational agents was shown to block the effect of estrogenic stimulation and reverse the process of excessive endometrial growth [1]. Progesterone is an essential factor involved in the development of endometrial receptivity, and it maintains the homeostasis of the female endocrine system by blocking the synthesis of gonadotropin in the hypothalamus [2]. Meanwhile, the expression of miR-320 is down-regulated in patients with breast cancer [3]. By increasing the expression of miR-320, progesterone may block the infiltration of cells from the trophectoderm and uterus. Progesterone has been shown to affect the expression of multiple

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来源期刊

Archives of Medical Science 医学-医学：内科

CiteScore

4.90

自引率

7.90%

发文量

139

审稿时长

1.7 months

期刊介绍： Archives of Medical Science (AMS) publishes high quality original articles and reviews of recognized scientists that deal with all scientific medicine. AMS opens the possibilities for young, capable scientists. The journal would like to give them a chance to have a publication following matter-of-fact, professional review by outstanding, famous medical scientists. Thanks to that they will have an opportunity to present their study results and/or receive useful advice about the mistakes they have made so far. The second equally important aim is a presentation of review manuscripts of recognized scientists about the educational capacity, in order that young scientists, often at the beginning of their scientific carrier, could constantly deepen their medical knowledge and be up-to-date with current guidelines and trends in world-wide medicine. The fact that our educational articles are written by world-famous scientists determines their innovation and the highest quality.