化学发散性环化反应的激进策略

IF 14 2区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Trends in Chemistry Pub Date : 2023-11-01 DOI:10.1016/j.trechm.2023.10.002

Ling-Tao Wang, Bo Zhou, Fa-Liang Liu, Wen-Ting Wei, Long-Wu Ye

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引用次数: 0

摘要

化学发散反应提供了一个独特的平台，可以从相似的起始材料获得扩展的化学空间和不同的分子结构。可调化学选择性的概念可以通过对底物或反应条件的简单修改来实现。在已知的化学发散转化中，自由基反应因其简单和高效而成为一个极其强大的工具箱，为实现可调的化学选择性创造了一条可行的途径。本文综述了2018年以来在控制自由基环化反应中不同反应途径方面的最新进展;受链长、取代基和自由基前体控制的底物依赖反应和以催化剂、碱、氧化还原试剂、溶剂等为主的条件控制反应。未来的研究途径也提出，以帮助扩大这一令人兴奋的领域。

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Radical strategies for chemodivergent cyclization reactions

Chemodivergent reactions provide a unique platform for accessing expanded chemical space and diverse molecular structures from similar starting materials. The concept of tunable chemoselectivity can be realized by simple modifications to the substrate or reaction conditions. Among the known chemodivergent transformations, radical reactions have emerged as an exceedingly powerful toolbox for their simplicity and efficiency, creating a feasible path to achieve tunable chemoselectivity. This review focuses on recent progress since 2018 in controlling the different reaction pathways in radical cyclization reactions; substrate-dependent reactions, controlled by chain length, substituents and radical precursors, and condition-controlled reactions, mainly dominated by catalysts, bases, redox reagents, solvents, etc. Future avenues for investigation are also presented to help expand this exciting field.

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来源期刊

Trends in Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

28.00

自引率

0.60%

发文量

138

期刊介绍： Trends in Chemistry serves as a new global platform for discussing significant and transformative concepts across all areas of chemistry. It recognizes that breakthroughs in chemistry hold the key to addressing major global challenges. The journal offers readable, multidisciplinary articles, including reviews, opinions, and short pieces, designed to keep both students and leading scientists updated on pressing issues in the field. Covering analytical, inorganic, organic, physical, and theoretical chemistry, the journal highlights major themes such as biochemistry, catalysis, environmental chemistry, materials, medicine, polymers, and supramolecular chemistry. It also welcomes articles on chemical education, health and safety, policy and public relations, and ethics and law.