乳腺癌单细胞侵袭性调节因子之间的新途径

IF 1.5 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Critical Reviews in Eukaryotic Gene Expression Pub Date : 2023-01-01 DOI:10.1615/critreveukaryotgeneexpr.2023050843

George Eliceiri

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引用次数: 0

摘要

众所周知，单个细胞的行为与其整体细胞群不同。目前的工作集中在控制癌症侵袭的蛋白质上。单个Dicer siRNA敲低HER4、CDC42和E-cadherin会降低SCP2(一种高度转移到骨和肾上腺的癌症单细胞后代)中MMP1 mRNA的水平。单个敲低β-catenin、CDC42、HER3和PI3K的γ催化亚基可提高SCP21的MMP1 mRNA水平，SCP21是同一肿瘤和患者的单细胞后代，骨和肾上腺转移率低。

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Novel pathways between invasiveness modulators in breast cancer single cells

Individual cells are known to behave differently than their whole populations of cells. The present work focused on proteins that control cancer invasiveness. Individual Dicer siRNA knockdown of HER4, CDC42, and E-cadherin decreased MMP1 mRNA levels in SCP2, a cancer single-cell progeny that is highly metastatic to bone and adrenal gland. Individual knockdown of β-catenin, CDC42, HER3, and the γ catalytic subunit of PI3K raised MMP1 mRNA levels in SCP21, a single-cell progeny of the same tumor and patient, with low metastasis to bone and adrenal.

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来源期刊

Critical Reviews in Eukaryotic Gene Expression 生物-生物工程与应用微生物

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource. Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered.