CPT1A在癌症中的致瘤作用和治疗意义

IF 0.8 4区生物学 Q4 BIOLOGY

Biocell Pub Date : 2023-01-01 DOI:10.32604/biocell.2023.027677

SHENGJIE SONG, ZHIZHOU SHI

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引用次数: 0

摘要

代谢重编程经常发生在大多数癌症中，其中脂肪酸氧化(FAO)通常是诱导的，并作为一种补偿机制来改善能量消耗。肉毒碱棕榈酰基转移酶1A (CPT1A)是粮农组织的限速酶，广泛参与肿瘤生长、转移和化疗/放射耐药。本文综述了CPT1A在肿瘤发生中的致癌作用和机制的最新进展，包括增殖和肿瘤生长、侵袭和转移以及肿瘤微环境。重要的是，CPT1A已被证明是一种用于诊断和预后预测的生物标志物，并被证明是一种候选治疗靶点，特别是用于治疗耐药和耐辐射肿瘤。综上所述，CPT1A在促进癌症进展中发挥着显著作用，是一个潜在的抗癌治疗靶点。

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CPT1A in cancer: Tumorigenic roles and therapeutic implications

Metabolic reprogramming frequently occurs in the majority of cancers, wherein fatty acid oxidation (FAO) is usually induced and serves as a compensatory mechanism to improve energy consumption. Carnitine palmitoyltransferase 1A (CPT1A) is the rate-limiting enzyme for FAO and is widely involved in tumor growth, metastasis, and chemo-/radio-resistance. This review summarizes the most recent advances in understanding the oncogenic roles and mechanisms of CPT1A in tumorigenesis, including in proliferation and tumor growth, invasion and metastasis, and the tumor microenvironment. Importantly, CPT1A has been shown to be a biomarker for diagnosis and prognosis prediction and proved to be a candidate therapeutic target, especially for the treatment of drug- and radiation-resistant tumors. In summary, CPT1A plays remarkable roles in promoting cancer progression and is a potential anticancer therapeutic target.

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来源期刊

Biocell 生物-生物学

CiteScore

1.50

自引率

16.70%

发文量

259

审稿时长

>12 weeks

期刊介绍： BIOCELL welcomes Research articles and Review papers on structure, function and macromolecular organization of cells and cell components, focusing on cellular dynamics, motility and differentiation, particularly if related to cellular biochemistry, molecular biology, immunology, neurobiology, and on the suborganismal and organismal aspects of Vertebrate Reproduction and Development, Invertebrate Biology and Plant Biology.