miRNA在头颈部鳞状细胞癌中的作用:个体化肿瘤学的前景广阔但仍很遥远

IF 1.2 Q4 ONCOLOGY

Reports of Practical Oncology and Radiotherapy Pub Date : 2023-10-05 DOI:10.5603/rpor.96666

Joanna Kozłowska-Masłoń, Kacper Guglas, Tomasz Kolenda, Katarzyna Lamperska, Izabela Makałowska

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引用次数: 0

摘要

头颈部鳞状细胞癌是世界上最常见和最致命的癌症之一。缺乏适当的预防性筛查试验，发现晚，这些肿瘤的高度异质性是治疗效果不理想的主要原因，因此，对患者不利的结果。提高这类癌症的诊断和治疗质量的一个机会是microRNAs (miRNAs)——作为生物标志物和治疗靶点具有巨大潜力的分子。本文旨在介绍这些短链非编码rna (ncRNAs)的特征，并总结目前关于它们在肿瘤学中应用的报道，重点是针对患者需求的医疗策略。

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miRNA in head and neck squamous cell carcinomas: promising but still distant future of personalized oncology

Head and neck squamous cell carcinoma is one of the most common and fatal cancers worldwide. Lack of appropriate preventive screening tests, late detection, and high heterogeneity of these tumors are the main reasons for the unsatisfactory effects of therapy and, consequently, unfavorable outcomes for patients. An opportunity to improve the quality of diagnostics and treatment of this group of cancers are microRNAs (miRNAs) — molecules with a great potential both as biomarkers and therapeutic targets. This review aims to present the characteristics of these short non-coding RNAs (ncRNAs) and summarize the current reports on their use in oncology focused on medical strategies tailored to patients’ needs.

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来源期刊

Reports of Practical Oncology and Radiotherapy Multiple-

CiteScore

2.80

自引率

8.30%

发文量

115

审稿时长

16 weeks

期刊介绍： Reports of Practical Oncology and Radiotherapy is an interdisciplinary bimonthly journal, publishing original contributions in clinical oncology and radiotherapy, as well as in radiotherapy physics, techniques and radiotherapy equipment. Reports of Practical Oncology and Radiotherapy is a journal of the Polish Society of Radiation Oncology, the Czech Society of Radiation Oncology, the Hungarian Society for Radiation Oncology, the Slovenian Society for Radiotherapy and Oncology, the Polish Study Group of Head and Neck Cancer, the Guild of Bulgarian Radiotherapists and the Greater Poland Cancer Centre, affiliated with the Spanish Society of Radiotherapy and Oncology, the Italian Association of Radiotherapy and the Portuguese Society of Radiotherapy - Oncology.