在连续流微反应器中合成苯并萘胺

IF 2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Zhi-Yuan Jiang, Jing Hou, Le-Wu Zhan, Bin-Dong Li
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引用次数: 0

摘要

为了提高合成N-正丁基-N-(2-硝基-乙基)硝胺(BuNENA)的工艺安全性、产品纯度和生产效率,将自行设计的心形通道微反应器和履带式微反应器依次连接,构建了两级连续流微反应器系统。结果表明,当正丁基乙醇胺的流速为 1.00 mL.min- 1 时,心形通道微反应器的温度为 10 ℃,履带式微反应器的温度为 35 ℃,氯化锌与正丁基乙醇胺的摩尔比为 2%,硝酸与正丁基乙醇胺的摩尔比为 2.4,氯化锌与正丁基乙醇胺的摩尔比为 2.4,结果最佳。在此条件下,反应时间缩短至 300 秒,BuNENA 的纯度高达 98.1%,收率为 87.1%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Synthesis of BuNENA in a continuous flow microreactor

Synthesis of BuNENA in a continuous flow microreactor

Synthesis of BuNENA in a continuous flow microreactor

In order to improve process safety, product purity, and production efficiency in the synthesis of N-n-butyl-N-(2-nitroxy-ethyl)nitramine (BuNENA), a two-stage continuous flow microreactor system was constructed by sequentially connecting the self-designed heart-shaped channel microreactor and the caterpillar microreactor. n-Butylethanolamine was used as the raw material, nitric acid and acetic anhydride were used as the nitrating agents. The results showed that when the flow rate of n-butylethanolamine was 1.00 mL.min− 1, the temperature of the heart-shaped channel microreactor was 10 ℃, the temperature of the caterpillar microreactor was 35 ℃, the molar ratio of ZnCl2 to n-butylethanolamine was 2%, the molar ratio of nitric acid to n-butylethanolamine was 2.4, and the molar ratio of ZnCl2 to n-butylethanolamine was 2.4, the result was best. Under the conditions, the reaction time was shortened to 300 s, the purity of BuNENA was up to 98.1%, and the yield was 87.1%.

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来源期刊
Journal of Flow Chemistry
Journal of Flow Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
6.40
自引率
3.70%
发文量
29
审稿时长
>12 weeks
期刊介绍: The main focus of the journal is flow chemistry in inorganic, organic, analytical and process chemistry in the academic research as well as in applied research and development in the pharmaceutical, agrochemical, fine-chemical, petro- chemical, fragrance industry.
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