{"title":"环磷酰胺对MRL1/1和NZB/WF1小鼠Peyer’s斑块的影响。","authors":"H Yoshioka, T Sugiyama, T Kita","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>MRL1/1 & NZB/WF1 female mice were treated with high-dose cyclophosphamide (20 mg/kg/week), and the distribution of T cells in the Peyer's patches was examined in treated and untreated mice. A multiple layering technique was used for immunohistochemical detection of the lymphocyte surface antigens of T cells (Thy1.2, L3T4, Lyt2). High-dose cyclophosphamide inhibited the increase of the T cell population of MRL1/1 female mice with age, but little change was observed NZB/WF1 female mice.</p>","PeriodicalId":73745,"journal":{"name":"Journal of Experimental Pathology","volume":"5 1","pages":"19-27"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effect of cyclophosphamide on the Peyer's patches in MRL1/1 and NZB/WF1 mice.\",\"authors\":\"H Yoshioka, T Sugiyama, T Kita\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>MRL1/1 & NZB/WF1 female mice were treated with high-dose cyclophosphamide (20 mg/kg/week), and the distribution of T cells in the Peyer's patches was examined in treated and untreated mice. A multiple layering technique was used for immunohistochemical detection of the lymphocyte surface antigens of T cells (Thy1.2, L3T4, Lyt2). High-dose cyclophosphamide inhibited the increase of the T cell population of MRL1/1 female mice with age, but little change was observed NZB/WF1 female mice.</p>\",\"PeriodicalId\":73745,\"journal\":{\"name\":\"Journal of Experimental Pathology\",\"volume\":\"5 1\",\"pages\":\"19-27\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1990-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Experimental Pathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Experimental Pathology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The effect of cyclophosphamide on the Peyer's patches in MRL1/1 and NZB/WF1 mice.
MRL1/1 & NZB/WF1 female mice were treated with high-dose cyclophosphamide (20 mg/kg/week), and the distribution of T cells in the Peyer's patches was examined in treated and untreated mice. A multiple layering technique was used for immunohistochemical detection of the lymphocyte surface antigens of T cells (Thy1.2, L3T4, Lyt2). High-dose cyclophosphamide inhibited the increase of the T cell population of MRL1/1 female mice with age, but little change was observed NZB/WF1 female mice.
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