Developing odontoma (ameloblastic fibro-odontoma) of the mandible: Report of a case with radiological, histopathological and immunohistochemical studies

We report a case of ameloblastic fibro-odontoma (AFO) in the second molar region of the left mandible of an 8-year-old girl. Cone beam computed tomography revealed a spatial relationship between the lesion and the gubernaculum tract of an unerupted second molar. Histologically, characteristic multinodular growth of discrete tooth germ-like structures supported the non-neoplastic hamartomatous nature of the lesion. The pattern and degree of syndecan-1 and D2-40 immunoexpression in the epithelial component varied, probably reflecting different stages of maturation. In view of the patient’s age (<13 years) and the size of the lesion (<2 cm), the present AFO was likely a developing odontoma.